The Synergistic Effects of AIH and FES in Persons With MS (NCT06413602)
🩺 Plain-English Summary (8th-Grade Level)
The purpose of this study is to examine how neuromuscular electrical stimulation (NMES), may synergistically enhance corticospinal excitability in people with relapsing form multiple sclerosis (MS). This is an important intermediate step to evaluate the potential of AIH + NMES as a plasticity-priming strategy for more efficacious interventions for persons with MS. This study will measure ankle torque generation and amplitude of motor evoked potentials (MEPs) using a repeated measures study design in order to better understand the effects of AIH combined with NMES, as compared to only receiving NMES, and only receiving AIH.
Who can join: To join this study, participants generally need to meet the listed inclusion criteria (6 items) and avoid the listed exclusions (20 items).
Location: Shirley Ryan AbilityLab — Chicago, Illinois
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistCheck every box below. If you can check all of them, you may meet the study's basic screening requirements (final eligibility is confirmed by the site team).
Usually NOT eligible if any of the following apply:
- Exclusion Criteria for persons with MS:
- Uncontrolled hypertension or hypotension (outside 140/90 and 90/60 mmHg)
- History of epilepsy or seizures Inclusion Criteria for uninjured controls:
- Age ≥18 years and ≤75 years
- Safe to participate in TMS (TMS questionnaire) Exclusion Criteria for uninjured controls:
- Uncontrolled hypertension or hypotension (outside 140/90 and 90/60 mmHg)
- History of epilepsy or seizures Exclusion criteria to TMS participation for persons with MS and uninjured controls:
- Uncontrolled medical problems affecting the lungs (pulmonary diseases including chronic obstructive pulmonary disease), the heart (cardiovascular diseases) or the musculoskeletal system (orthopedic diseases)
- Premorbid, ongoing major depression or psychosis, altered cognitive status
- History of stroke
- Metal in head (e.g., surgical clips, shrapnel)
- History of seizures or epilepsy diagnosis
🔍 Extracted verbatim from the official NIH eligibility criteria. Always confirm with the study coordinator.
📍 All Participating Trial Locations (1 Sites)
- Shirley Ryan AbilityLab — Chicago, Illinois
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.