🏛️ Verified NIH Record • Updated 2026-02-27

A Clinical Study of Efinopegdutide in People With Compensated Cirrhosis Due to Steatohepatitis (MK-6024-017) (NCT06465186)

🔵 Active, Not Recruiting Phase2 💊 Investigational Drug / Biologic Sponsor: Merck Sharp & Dohme LLC

🩺 Plain-English Summary (8th-Grade Level)

Researchers are looking for ways to treat a type of liver disease caused by elevated liver fat, called metabolic dysfunction-associated steatohepatitis (MASH). MASH was formerly called non-alcoholic steatohepatitis (NASH). Researchers want to learn if a study medicine called efinopegdutide can treat MASH.The goals of this study are to learn: * If efinopegdutide can lower the amount of fat, inflammation, and scarring (fibrosis) in the liver * About the safety of efinopegdutide and how well people tolerate it

Who can join: To join this study, participants generally need to meet the listed inclusion criteria (3 items) and avoid the listed exclusions (6 items).

Location: The Institute for Liver Health II dba Arizona Clinical Trial-The Institute for Liver Health ( Site 0149) — Chandler, Arizona

📋 "Do I Qualify?" — 1-Minute Self Screener

Instant Checklist

Check every box below. If you can check all of them, you may meet the study's basic screening requirements (final eligibility is confirmed by the site team).

Usually NOT eligible if any of the following apply:

  • Exclusion Criteria: The main exclusion criteria include but are not limited to the following:
  • Has history of a liver disease other than MASH, for example, Hepatitis B or C, drug-induced liver disease, or autoimmune liver disease
  • Has history of type 1 diabetes
  • Had a bariatric surgical procedure less than 5 years before entry into the study
  • History of pancreatitis
  • Major illnesses like recent (within 6 months of study entry) episodes of heart problems, such as congestive heart failure, unstable angina, heart attack, stroke, or mini-stroke

🔍 Extracted verbatim from the official NIH eligibility criteria. Always confirm with the study coordinator.

📍 All Participating Trial Locations (68 Sites)

  • The Institute for Liver Health II dba Arizona Clinical Trial-The Institute for Liver Health ( Site 0149) — Chandler, Arizona
  • Arizona Clinical Trials ( Site 0158) — Flagstaff, Arizona
  • The Institute for Liver Health II dba Arizona Liver Health - Peoria ( Site 0120) — Peoria, Arizona
  • The Institute for Liver Health II dba Arizona Liver Health-Tucson ( Site 0111) — Tucson, Arizona
  • California Liver Research Institute ( Site 0113) — Pasadena, California
  • Acclaim Clinical Research ( Site 0137) — San Diego, California
  • Velocity Clinical Research, Panorama City ( Site 0124) — Van Nuys, California
  • Rocky Mountain Gastroenterology ( Site 0127) — Littleton, Colorado
  • Synergy Healthcare ( Site 0118) — Bradenton, Florida
  • Homestead Associates in Research, Inc. ( Site 0139) — Homestead, Florida
  • Florida Research Institute ( Site 0116) — Lakewood Rch, Florida
  • Floridian Clinical Research, LLC ( Site 0109) — Miami Lakes, Florida
  • Southeast Clinical Research Center ( Site 0119) — Dalton, Georgia
  • Delta Research Partners ( Site 0160) — Bastrop, Louisiana
  • Louisiana Research Center ( Site 0161) — Shreveport, Louisiana
  • Woodholme Gastroenterology Associates-Woodholme Gastroenterology Associates ( Site 0130) — Glen Burnie, Maryland
  • Velocity Clinical Research Rockville ( Site 0143) — Rockville, Maryland
  • Huron Gastroenterology ( Site 0102) — Ypsilanti, Michigan
  • The Machuca Foundation ( Site 0115) — Las Vegas, Nevada
  • Excel Clinical Research, LLC ( Site 0101) — Las Vegas, Nevada
  • Southwest Gastroenterology Associates ( Site 0129) — Albuquerque, New Mexico
  • Coastal Research Institute - Fayetteville ( Site 0159) — Fayetteville, North Carolina
  • Lucas Research, Inc ( Site 0105) — Morehead City, North Carolina
  • Texas Clinical Research Institute ( Site 0126) — Arlington, Texas
  • Pinnacle Clinical Research ( Site 0104) — Austin, Texas

💰 Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
🏛️ View Official NIH Record ↗