🏛️ Verified NIH Record • Updated 2026-08-27
A Study of JNJ-64042056 in Participants With Preclinical Alzheimer's Disease (NCT06544616)
🔵 Active, Not Recruiting Phase2 💊 Investigational Drug / Biologic Sponsor: Janssen Pharmaceutica N.V., Belgium
🩺 Plain-English Summary (8th-Grade Level)
The purpose of this study is to assess whether JNJ-64042056 affects the spread and build up of tau (a protein in brain) when compared with placebo, using brain scan (tau PET) to determine results from specific areas of the brain.
Who can join: To join this study, participants generally need to meet the listed inclusion criteria (5 items) and avoid the listed exclusions (6 items).
Location: Xenoscience Inc. — Phoenix, Arizona
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistCheck every box below. If you can check all of them, you may meet the study's basic screening requirements (final eligibility is confirmed by the site team).
Usually NOT eligible if any of the following apply:
- Exclusion Criteria:
- History consistent with or known autosomal dominant AD (mutation identified in the family and/or participant)
- Fulfills diagnostic criteria for Alzheimer's Dementia or non-Alzheimer's Dementia, including, but not limited to Frontotemporal Dementia (FTD), Diffuse Lewy Body Dementia (DLBD), Vascular Dementia (VAD), alcoholic dementia, Parkinson's dementia, Korsakov, Creutzfeldt-Jakob or other prion diseases, Posterior Cortical Atrophy
- Diagnosis of Mild Cognitive Impairment (MCI)
- Vitamin B12 or folate levels below the central laboratory lower limit of normal, unless the investigator determines that supplementation is not required after randomization
- History of or current neurological disease other than preclinical AD that may make interpretation of possible new neurological signs or symptoms difficult
🔍 Extracted verbatim from the official NIH eligibility criteria. Always confirm with the study coordinator.
📍 All Participating Trial Locations (90 Sites)
- Xenoscience Inc. — Phoenix, Arizona
- Irvine Clinical Research — Irvine, California
- Esperanza Clinical — Murrieta, California
- Artemis Institute for Clinical Research Riverside — Riverside, California
- Artemis Institute for Clinical Research San Diego — San Diego, California
- Yale University School Of Medicine — New Haven, Connecticut
- JEM Research LLC — Atlantis, Florida
- Excel Medical Clinical Trials, LLC — Boca Raton, Florida
- K2 Medical Research Winter Garden — Clermont, Florida
- Clinical NeuroScience Solutions Inc — Jacksonville, Florida
- K2 Medical Research Lady Lake — Lady Lake, Florida
- K2 Medical Research Maitland — Maitland, Florida
- Merritt Island Medical Research, LLC — Merritt Island, Florida
- Headlands Research Orlando — Orlando, Florida
- Alzheimers Research and Treatment Center Stuart — Stuart, Florida
- K2 Medical Research Tampa — Tampa, Florida
- Charter Research — The Villages, Florida
- Alzheimers Research and Treatment Center Wellington — Wellington, Florida
- Palm Beach Neurology and Premier Research Institute — West Palm Beach, Florida
- Great Lakes Clinical Trials Chicago — Chicago, Illinois
- Great Lakes Clinical Trials Gurnee — Gurnee, Illinois
- Quest Research Institute — Farmington Hills, Michigan
- Hattiesburg Clinic — Hattiesburg, Mississippi
- The Cognitive and Research Center of New Jersey LLC — Springfield, New Jersey
- Neurological Associates of Albany, PC — Albany, New York
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.