Who is eligible for clinical trial NCT06578429?

Participants must meet protocol criteria for Methamphetamine Use Disorder. Confirm exact inclusion and exclusion requirements with the study coordinator.

Does clinical trial NCT06578429 provide travel or cost reimbursement?

Check with the site coordinator at the participating facility for travel and lodging stipend availability, and for which routine-care costs are covered.

🏛️ Verified NIH Record • Updated 2025-09-10

Deep TMS of Neural Circuits Associated With Stimulant Use Disorder (NCT06578429)

🟢 Recruiting Observational / Diagnostic ⚙️ Medical Device Protocol Sponsor: Stanford University

🩺 Plain-English Summary (8th-Grade Level)

This study aims to evaluate the efficacy of deep transcranial magnetic stimulation (dTMS) as a treatment for Veterans with a methamphetamine use disorder (MUD).

Who can join: To join this study, participants generally need to meet the listed inclusion criteria (7 items) and avoid the listed exclusions (13 items).

Location: VA Palo Alto Health Care System — Palo Alto, California

📋 "Do I Qualify?" — 1-Minute Self Screener

Instant Checklist

Check every box below. If you can check all of them, you may meet the study's basic screening requirements (final eligibility is confirmed by the site team).

Must be within the age range of 25-75.
Participants must meet Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5) criteria for moderate to severe MUD (≥4 diagnostic symptoms).
Participants must be able to obtain a Motor Threshold (MT), which will be determined during the screening process.
Participants must have an adequately stable condition and environment to enable attendance at scheduled clinic visits.
Participants must be able to read, verbalize, understand, and voluntarily sign the Informed Consent Form prior to participation in study procedures in English.
If participants are on a medication regimen for comorbid symptoms, that regimen will be stable for the duration of the study and patient will be willing to remain on this regimen during the treatment phase.
Participants must be fluent in English

Usually NOT eligible if any of the following apply:

Exclusion criteria:
Transcranial magnetic stimulation (TMS) and magnetic resonance imaging (MRI) contraindications: such as a cardiac pacemaker, cochlear implant, or an implanted device (deep brain stimulation, ferromagnetic metal in the head and body, claustrophobia, pregnant or breastfeeding or other ferromagnetic device/object in the head and body within 30 cm of the treatment coil.
General medical condition, disease, or neurological disorder that interferes with the assessments or participation.
Unable to safely withdraw, at least two weeks prior to treatment, from medications that increase seizure risk.
Current substance abuse as determined by positive toxicology screen
Have a mass lesion, cerebral infarct, or other active CNS disease, including a seizure disorder.
A recent suicide attempt (defined as within the last 30 days) or presence of current suicidal plan or intent. Patients at risk for suicide will be required to establish a written safety plan involving their primary therapist before entering the study.
Severe impediment to vision, hearing and/or hand movement, as this is likely to interfere with the ability to follow study protocols.
Greater than mild traumatic brain injury (defined as greater than 10 minutes loss of consciousness).
Taking benzodiazepines or neuroleptic medications, or any medication known to alter seizure threshold.
Acute or unstable chronic illness.
Current or lifetime history of bipolar disorder or psychosis.

🔍 Extracted verbatim from the official NIH eligibility criteria. Always confirm with the study coordinator.

📍 All Participating Trial Locations (1 Sites)

VA Palo Alto Health Care System — Palo Alto, California

💰 Cost, Insurance & Patient Rights

100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

🏛️ View Official NIH Record ↗