A Study to Evaluate ALN-BCAT in Patients With Hepatocellular Carcinoma (NCT06600321)
🩺 Plain-English Summary (8th-Grade Level)
The purpose of the dose escalation part of the study is to characterize the safety and tolerability of ALN-BCAT as monotherapy and in combination with pembrolizumab; and to determine the recommended dose(s) for expansion (RDFE) of ALN-BCAT as monotherapy and in combination with pembrolizumab. The purpose of the dose expansion part of the of the study is to evaluate the antitumor activity of ALN-BCAT as monotherapy and in combination with pembrolizumab; to characterize the safety and tolerability of ALN-BCAT as monotherapy and in combination with pembrolizumab.
Who can join: To join this study, participants generally need to meet the listed inclusion criteria (4 items) and avoid the listed exclusions (4 items).
Location: Clinical Trial Site — Phoenix, Arizona
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistCheck every box below. If you can check all of them, you may meet the study's basic screening requirements (final eligibility is confirmed by the site team).
Usually NOT eligible if any of the following apply:
- Exclusion Criteria:
- Has fibrolamellar HCC, sarcomatoid HCC, or mixed cholangio-HCC tumors
- Has symptomatic extrahepatic disease
- Has received anti-cancer therapy or investigational drugs ≤3 weeks prior to the first dose of study drug Note: other protocol defined inclusion / exclusion criteria apply
🔍 Extracted verbatim from the official NIH eligibility criteria. Always confirm with the study coordinator.
📍 All Participating Trial Locations (23 Sites)
- Clinical Trial Site — Phoenix, Arizona
- Clinical Trial Site — La Jolla, California
- Clinical Trial Site — Los Angeles, California
- Clinical Trial Site — Jacksonville, Florida
- Clinical Trial Site — Atlanta, Georgia
- Clinical Trial Site — Chicago, Illinois
- Clinical Trial Site — Ann Arbor, Michigan
- Clinical Trial Site — Rochester, Minnesota
- Clinical Trial Site — New York, New York
- Clinical Trial Site — New York, New York
- Clinical Trial Site — Cleveland, Ohio
- Clinical Trial Site — Pittsburgh, Pennsylvania
- Clinical Trial Site — Dallas, Texas
- Clinical Trial Site — Houston, Texas
- Clinical Trial Site — San Antonio, Texas
- Clinical Trial Site — Richmond, Virginia
- Clinical Trial Site — Milan,
- Clinical Trial Site — Rozzano,
- Clinical Trial Site — Verona,
- Clinical Trial Site — Busan,
- Clinical Trial Site — Seongnam,
- Clinical Trial Site — Seongnam,
- Clinical Trial Site — Seoul,
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.