Who is eligible for clinical trial NCT06602141?

Participants must meet protocol criteria for Obesity. Confirm exact inclusion and exclusion requirements with the study coordinator.

Does clinical trial NCT06602141 provide travel or cost reimbursement?

Check with the site coordinator at the participating facility for travel and lodging stipend availability, and for which routine-care costs are covered.

🏛️ Verified NIH Record • Updated 2026-03-24

Assessments of Adipogenesis, Lipid Turnover and Cellular Composition in Adipose Tissue in Response to Endurance Exercise (NCT06602141)

🟢 Recruiting Observational / Diagnostic 🩺 Clinical Procedure Protocol Sponsor: AdventHealth Translational Research Institute

🩺 Plain-English Summary (8th-Grade Level)

The purpose of this research study is to study the effects of endurance exercise training on adipose (fat) tissue quality and insulin sensitivity in men and women.

Who can join: To join this study, participants generally need to meet the listed inclusion criteria (9 items) and avoid the listed exclusions (48 items).

Location: AdventHealth Translational Research Institute — Orlando, Florida

📋 "Do I Qualify?" — 1-Minute Self Screener

Instant Checklist

Check every box below. If you can check all of them, you may meet the study's basic screening requirements (final eligibility is confirmed by the site team).

Men and pre-menopausal women;
18-45 years of age;
BMI 30.0-40.0 kg/m2;
For women, if not using pharmaceutical (hormonal) contraception (i.e. birth control pills, vaginal ring, injections, or implant), must agree to use either a double barrier method as a form of birth control to prevent pregnancy (i.e. male condom with spermicide, with or without cervical cap or diaphragm); use implants or intrauterine contraceptive devices; have a tubal ligation (surgically sterile); practice abstinence; or be in an established relationship with a vasectomized or same sex partner during the entire duration of the study;
Able to speak and understand written and spoken English;
Sedentary defined as self-reporting no more than 1 day per week, lasting no more than 60 minutes, of regular (structured) endurance or resistance exercise in the past year.
Must be willing to be randomized to either study group;
Must be willing to adhere to all study procedures.
Participant has voluntarily signed and dated an informed consent form, approved by an Institutional Review Board/Independent Ethics Committee, and provided Health Insurance Portability and Accountability Act authorization (HIPAA) or other privacy authorization prior to any participation in study.

Usually NOT eligible if any of the following apply:

Exclusion Criteria:
Self-reported unstable body weight in the last 3 months (\> ±5%);
Significant changes in the quality of the diet or the level of physical activity within the last 3 months;
Weight \>396 lb (180 kg);
Diagnosis of Type 1 or Type 2 diabetes mellitus;
Fasting blood glucose ≥126 mg/dL;
HbA1c ≥ 6.5%
Blood pressure \>140/90 mmHg ;
Self-reported history or presence of the following cardiovascular conditions: congestive heart failure, coronary artery disease, significant valvular disease, congenital heart disease, serious arrhythmia, stroke, symptomatic peripheral artery disease, stable angina, myocardial infarction or coronary revascularization within 6 months; clinically significant abnormalities on ECG, presence of cardiac pacemaker, or implanted cardiac defibrillator; inability to complete the VO2max test;
Anemia (hemoglobin \<12 g/dl in men or 11 g/dl in women; Hct \<34%);
Kidney disease (creatinine \>1.6 mg/dl or estimated glomerular filtration rate \<60 mL/min/1.73m2);
Abnormal liver enzymes (\>2 times the upper limit of normal) that are clinically significant;

🔍 Extracted verbatim from the official NIH eligibility criteria. Always confirm with the study coordinator.

📍 All Participating Trial Locations (2 Sites)

AdventHealth Translational Research Institute — Orlando, Florida
Pennington Biomedical Research Center — Baton Rouge, Louisiana

💰 Cost, Insurance & Patient Rights

100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

🏛️ View Official NIH Record ↗