Who is eligible for clinical trial NCT06727552?

Participants must meet protocol criteria for Atopic Dermatitis. Confirm exact inclusion and exclusion requirements with the study coordinator.

Does clinical trial NCT06727552 provide travel or cost reimbursement?

Check with the site coordinator at the participating facility for travel and lodging stipend availability, and for which routine-care costs are covered.

🏛️ Verified NIH Record • Updated 2026-08-10

A Study of Barzolvolimab in Patients With Atopic Dermatitis (NCT06727552)

🔵 Active, Not Recruiting Phase2 💊 Investigational Drug / Biologic Sponsor: Celldex Therapeutics

🩺 Plain-English Summary (8th-Grade Level)

The purpose of this study is to assess the efficacy and safety of barzolvolimab in adults with Atopic Dermatitis

Who can join: To join this study, participants generally need to meet the listed inclusion criteria (9 items) and avoid the listed exclusions (5 items).

Location: Cahaba Dermatology & Skin Health Center, LLC — Birmingham, Alabama

📋 "Do I Qualify?" — 1-Minute Self Screener

Instant Checklist

Check every box below. If you can check all of them, you may meet the study's basic screening requirements (final eligibility is confirmed by the site team).

Male or female ≥ 18 years of age
Diagnosis of chronic atopic dermatitis (AD) for at least 1 year
Onset of symptoms at least 1 year prior and current symptoms consistent with moderate to severe AD as defined by:
EASI ≥ 12 at Visit 1 and EASI ≥ 16 at Visit 2
Body Surface Area of Involvement (BSA) ≥ 10% at Visit 1 and Visit 2
IGA score ≥ 3 at Visit 1 and Visit 2
Severe itch, defined by weekly average of daily PP-NRS score of ≥ 5, during the 7 days prior to treatment
Documented history of inadequate response to treatment with topical medications or for whom topical medications are otherwise medically inadvisable.
Willing and able to complete a daily symptom electronic diary for the duration of the study and adhere to the study visit schedule.

Usually NOT eligible if any of the following apply:

Exclusion Criteria:
Any other active pruritic skin diseases that would confound AD assessments based on the Investigator's clinical judgment.
Phototherapy with ultraviolet (UV) A or UVB within 4 weeks of Visit 1.
Planned or anticipated use of any prohibited medications at any time during the study.
Prior receipt of barzolvolimab or other anti-KIT therapy. There are additional criteria that your study doctor will review with you to confirm you are eligible for the study.

🔍 Extracted verbatim from the official NIH eligibility criteria. Always confirm with the study coordinator.

📍 All Participating Trial Locations (33 Sites)

Cahaba Dermatology & Skin Health Center, LLC — Birmingham, Alabama
Ohara Aivaz MD Dermatology — Beverly Hills, California
Advanced Dermatology Center - Burbank — Burbank, California
310 Clinical Research — Inglewood, California
Avance Trials — Laguna Niguel, California
LA Universal Research Center, Inc. — Los Angeles, California
UCLA Division of Dermatology — Los Angeles, California
Dynasty Dermatology — Pasadena, California
Acclaim Clinical Research — San Diego, California
FOMAT Medical Research - Allergy, Asthma, & Immunology Medical Group — Ventura, California
Focus Clinical Research — West Hills, California
Direct Helpers Research Center — Hialeah, Florida
International Dermatology Research Inc - Miami — Miami Lakes, Florida
Sarasota Clinical Research — Sarasota, Florida
Well Pharma Medical Research Corporation — South Miami, Florida
Centricity Research Columbus Dermatology — Columbus, Georgia
Georgia Skin and Cancer Clinic — Savannah, Georgia
Treasure Valley Medical Research — Boise, Idaho
Center for Medical Dermatology + Immunology Research — Chicago, Illinois
Sneeze Wheeze and Itch Associates LLC — Normal, Illinois
Equity Medical LLC — Bowling Green, Kentucky
Allergy and Asthma Specialists PSC — Owensboro, Kentucky
Onyx Clinical Research - Michigan — Flint, Michigan
Revival Research Institute, LLC — Troy, Michigan
Excel Clinical Research — Las Vegas, Nevada

💰 Cost, Insurance & Patient Rights

100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

🏛️ View Official NIH Record ↗