Who is eligible for clinical trial NCT06747871?

Participants must meet protocol criteria for Chronic Pain. Confirm exact inclusion and exclusion requirements with the study coordinator.

Does clinical trial NCT06747871 provide travel or cost reimbursement?

Check with the site coordinator at the participating facility for travel and lodging stipend availability, and for which routine-care costs are covered.

🏛️ Verified NIH Record • Updated 2026-01-07

Opioids, Low Nicotine Cigarettes, and Chronic Pain (NCT06747871)

🟢 Recruiting Observational / Diagnostic 🧠 Behavioral & Psychological Program Sponsor: Duke University

🩺 Plain-English Summary (8th-Grade Level)

The purpose of this study is to evaluate the effects of switching to very low nicotine content (VLNC) cigarettes versus normal nicotine content (NNC) cigarettes on craving, withdrawal, and pain among individuals with chronic pain who smoke cigarettes daily and are attending office-based buprenorphine treatment (OBBT).

Who can join: To join this study, participants generally need to meet the listed inclusion criteria (7 items) and avoid the listed exclusions (12 items).

Location: North Pavilion — Durham, North Carolina

📋 "Do I Qualify?" — 1-Minute Self Screener

Instant Checklist

Check every box below. If you can check all of them, you may meet the study's basic screening requirements (final eligibility is confirmed by the site team).

Aged 21+ years who smoke cigarettes daily
Chronic non-cancer musculoskeletal pain secondary to structural changes (e.g., low back pain, osteoarthritis)
Have received stable office-based buprenorphine treatment for opioid use disorder for at least 30 days
Self-report smoking at least 10 cigarettes/day
Expired breath carbon monoxide (CO) level \>8 ppm
Have a smartphone capable of running software for ecological momentary assessment
Open to exploring the possibility of quitting smoking

Usually NOT eligible if any of the following apply:

Exclusion Criteria:
Pain specifically due to cancer
Other significant health problems
Major surgery within the past 6 months or planned surgery within the timeframe of the study
Current disability litigation
Use of electronic cigarettes or other non-cigarette tobacco products \> 9 of the past 30 days
Current use of nicotine replacement therapy or other cessation treatment
Current daily or near-daily cannabis use
History of psychotic disorder
Acute suicidality or current unstable psychiatric disorder
Positive pregnancy test
Actively seeking smoking cessation treatment

🔍 Extracted verbatim from the official NIH eligibility criteria. Always confirm with the study coordinator.

📍 All Participating Trial Locations (1 Sites)

North Pavilion — Durham, North Carolina

💰 Cost, Insurance & Patient Rights

100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

🏛️ View Official NIH Record ↗