Safety and Efficacy Study of Sivopixant, Acetazolamide and SASS-001 in Sleep Apnea (NCT06776432)

Usually NOT eligible if any of the following apply:

• Exclusion criteria Vital signs and symptoms Sustained SpO2\<93% during wakefulness or mean SpO2\<88% during sleep, calculated from PSG at screening Dyspnea at rest or patients with heart failure class IV NYHA Blood pressure \<90/50 mmHg or \>160/100 mmHg at V1. Medical Conditions Recent (\<3 months) episode of acute myocardial infarction or acute decompensated heart failure. History of stroke. History of sustained ventricular tachyarrhythmias or other severe arrhythmias without defibrillator implanted. Heart failure primarily caused by valvular, post-partum cardiomyopathy or active myocarditis History of obesity-hypoventilation syndrome or respiratory disturbance due to opioids. History of bronchiectasis and uncontrolled asthma. History of severe chronic obstructive pulmonary disease (COPD) with a forced expiratory volume in 1 second (FEV1) \<50% of predicted (European Respiratory Society criteria) Started treatment with β-blockers \<3 months before screening. Patients not taking β-blockers or taking β-blockers for \>3 months can be enrolled. Narcolepsy, restless leg syndrome requiring medication, REM sleep behavior disorder. Pronounced anatomical abnormalities of upper airway (adenoid vegetations, grade ≥3 tonsillar hypertrophy, etc.), pronounced micrognathia, or pronounced incomplete development of the lower jaw. History of schizophrenia, schizoaffective disorder or bipolar disorder according to Diagnostic and Statistical Manual of Mental Disorders-5 (DSM-5) or International Classification of Disease tenth edition criteria. Medically unexplained positive screen for drugs of abuse (excluding THC/marijuana) or history of substance use disorder as defined in DSM-V within 24 months prior to Screening Visit. A significant illness or infection requiring medical treatment in the past 30 days as determined by investigator. Clinically significant cognitive dysfunction as determined by investigator. Women who are pregnant or nursing. History of kidney stones Prior/Concomitant Therapy Participants with a history of using devices for OSA treatment, including CPAP, oral or nasal devices, or positional devices, may enroll as long as the devices have not been used for at least 1 week before the baseline SpO2 assessments and are not used during participation in the study (through V7). Patients that are non-compliant to CPAP (less than 4hr/night for 5 days/week) can be enrolled, as well as patients who are naïve to PAP and patients who discontinued PAP previously. PAP compliant patients cannot be enrolled. History of chronic oxygen therapy. Concomitant use of medications from the list of disallowed medications. Prior/Concurrent Clinical Study Experience Use of another investigational agent within 30 days or 5 half-lives, whichever is longer, prior to dosing. Diagnostic Assessments Hepatic cirrhosis, hepatictransaminases \> 2X the upper limit of normal (ULN), total bilirubin \>1.5X ULN (unless confirmed Gilbert syndrome), estimated glomerular filtration rate \< 40 ml/min. Participants with reduced sodium and/or potassium blood serum levels. Participants with suprarenal gland failure. Participants with hyperchloremic acidosis. Other Exclusions: Night- or shift-work sleep schedule which causes the major sleep period to be during the day. Employment as a commercial driver or operator of heavy or hazardous equipment. Typically smoking more than 10 cigarettes or 2 cigars per day, or inability to abstain from smoking during overnight PSG visits. Unwilling to use specified contraception. History of regular alcohol consumption of more than 14 standard units per week (males) or more than 7 standard units per week (females), or unwillingness to limit alcohol consumption to no greater than 2 units/day (males), 1 unit per day (females). Alcohol is not to be consumed within 3 hours of bedtime or on PSG nights. Unwilling to agree to limit during the study period caffeinated beverage intake (e.g., coffee, cola, tea) to 400 mg/day or less of caffeine, not to be used within 3 hours of bedtime. Any condition that in the investigator's opinion would present an unreasonable risk to the participant, including recent (\<1 year) motor vehicle accident due to drowsy driving, or which would interfere with their participation in the study or confound study interpretation. Participant considered by the investigator, for any reason, an unsuitable candidate to receive sivopixant or acetazolamide or unable or unlikely to understand or comply with the dosing schedule or study evaluations. Allergy to study drugs
• Note: Other protocol defined Inclusion/Exclusion criteria may apply