🏛️ Verified NIH Record • Updated 2026-07-01
Study of Trastuzumab Deruxtecan With Bevacizumab Versus Bevacizumab Monotherapy for First-line Maintenance in HER2-Expressing Ovarian Cancer (DESTINY-Ovarian01) (NCT06819007)
🟢 Recruiting Phase3 💊 Investigational Drug / Biologic Sponsor: Daiichi Sankyo
🩺 Plain-English Summary (8th-Grade Level)
This clinical trial is designed to evaluate the efficacy and safety of T-DXd in combination with bevacizumab versus bevacizumab monotherapy as first-line maintenance therapy, in participants with human epidermal growth factor 2 (HER2)-expressing (immunohistochemistry \[IHC\] 3+/2+/1+) advanced high-grade epithelial ovarian cancer.
Who can join: Review the eligibility criteria below.
Location: Disney Family Cancer Center — Burbank, California
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistFull eligibility criteria are available on the official NIH protocol. View the criteria ↗
📍 All Participating Trial Locations (208 Sites)
- Disney Family Cancer Center — Burbank, California
- Scripps Clinic — La Jolla, California
- Palo Alto Medical Foundation — Palo Alto, California
- Broward Health Medical Center — Fort Lauderdale, Florida
- Jupiter Medical Center — Jupiter, Florida
- Mount Sinai Medical Center — Miami Beach, Florida
- AdventHealth Cancer Institute — Orlando, Florida
- Woman's Care FL — St. Petersburg, Florida
- Nancy N. & J.C Lewis Cancer & Research Pavillion- St. Josephs/ Candler Health System — Savannah, Georgia
- Endeavor Health Evanston Kellogg Cancer Care Center — Evanston, Illinois
- Indiana University — Indianapolis, Indiana
- Trials365 LLC — Shreveport, Louisiana
- Greater Baltimore Medical Center — Towson, Maryland
- Massachusetts General Hospital — Boston, Massachusetts
- Dana-Farber Cancer Institute — Boston, Massachusetts
- Trinity Health St. Joseph Mercy Ann Arbor — Ann Arbor, Michigan
- Corewell Health — Grand Rapids, Michigan
- Minnesota Oncology Hematology PA — Minneapolis, Minnesota
- St. Vincent Gynecologic Oncology — Billings, Montana
- Valley Health System — Paramus, New Jersey
- Laura and Isaac Perlmutter Cancer Center at NYU Langone — New York, New York
- Icahn School of Medicine at Mount Sinai — New York, New York
- Columbia University — New York, New York
- UNC Hospital — Chapel Hill, North Carolina
- Miami Valley Hospital South — Centerville, Ohio
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.