GLP-1s to Enhance Lasting Optimal Weight (NCT06861439)
🩺 Plain-English Summary (8th-Grade Level)
The goal of this study is to examine how tirzepatide affects body composition, bone health, and physical performance in older adults over a nine-month period. Participants will take tirzepatide weekly, have clinic visits every 4 weeks, meet study doctor and registered dietitian every 4 weeks in person or video conference, attend group intervention sessions twice a month via video conference, weigh daily with a study-provided smart scale, keep a record of all foods and beverages consumed, and use a study-provided activity tracker to keep track of daily step counts.
Who can join: To join this study, participants generally need to meet the listed inclusion criteria (7 items) and avoid the listed exclusions (32 items).
Location: Wake Forest University Health Sciences — Winston-Salem, North Carolina
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistCheck every box below. If you can check all of them, you may meet the study's basic screening requirements (final eligibility is confirmed by the site team).
Usually NOT eligible if any of the following apply:
- Exclusion Criteria:
- dependent on a cane or walker or needing assistance with any activity of daily living
- history of mild cognitive impairment or dementia or cognitive impairment on Montreal Cognitive Assessment (MoCA score \<22)
- evidence of depressive symptoms (Center for Epidemiologic Studies Depression scale score =\>16
- use of \>1 tobacco product/day or 4/week or vaped \>1/week in past year
- excessive alcohol use in past month (\>7 drinks/week for women; \>14 drinks/week for men)
- weight loss or gain \>5% in past 3 months
- vegan or other severe dietary restriction
- history of binge eating disorder
- regular participation in high intensity aerobic or resistance exercise training \>150 mins/week
- severe arthritis, fracture, chronic injury, or other musculoskeletal disorder that prevents walking independently
- joint replacement or other orthopedic surgery in past 6 months or planned in next 12 months
🔍 Extracted verbatim from the official NIH eligibility criteria. Always confirm with the study coordinator.
📍 All Participating Trial Locations (1 Sites)
- Wake Forest University Health Sciences — Winston-Salem, North Carolina
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.