🏛️ Verified NIH Record • Updated 2026-05-12
Ketamine add-on Therapy for Established Status Epilepticus Treatment Trial (KESETT) (NCT06907173)
🟢 Recruiting Phase3 💊 Investigational Drug / Biologic Sponsor: University of Virginia
🩺 Plain-English Summary (8th-Grade Level)
The goal of this clinical trial is to determine if treatment of patients with two doses of ketamine plus levetiracetam versus levetiracetam alone leads to more effective control of status epilepticus.
Who can join: To join this study, participants generally need to meet the listed inclusion criteria (6 items) and avoid the listed exclusions (13 items).
Location: Banner University Medical Center - Tucson Campus — Tucson, Arizona
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistCheck every box below. If you can check all of them, you may meet the study's basic screening requirements (final eligibility is confirmed by the site team).
Usually NOT eligible if any of the following apply:
- Exclusion Criteria:
- Known pregnancy
- Prisoner
- Opt-out identification or otherwise known to be previously enrolled in KESETT
- Treatment with a second line anticonvulsant (FOS, PHT, VPA, LEV, phenobarbital, or other agents defined in the MoP) for this episode of SE
- Treatment with sedatives with anticonvulsant properties other than benzodiazepines for this episode of SE(propofol, etomidate, ketamine or other agents defined in the MoP)
- Endotracheal intubation prior to enrollment
- Acute traumatic brain injury clearly precedes seizures
- Scalp injury or burn preventing EEG placement
- Known allergy or other known contraindication to KET or LEV
- Hypoglycemia \< 50 mg/dL
- Hyperglycemia \> 400 mg/dL
🔍 Extracted verbatim from the official NIH eligibility criteria. Always confirm with the study coordinator.
📍 All Participating Trial Locations (52 Sites)
- Banner University Medical Center - Tucson Campus — Tucson, Arizona
- Ronald Reagan UCLA Medical Center — Los Angeles, California
- Children's Hospital Los Angeles — Los Angeles, California
- Stanford University Medical Center — Palo Alto, California
- UC Davis Medical Center — Sacramento, California
- San Francisco General Hospital — San Francisco, California
- UCSF Medical Center — San Francisco, California
- Yale New Haven Hospital — New Haven, Connecticut
- Christiana Hospital — Newark, Delaware
- Nemours Children's Hospital — Wilmington, Delaware
- Children's National Medical Center — Washington D.C., District of Columbia
- Orlando Regional Medical Center — Orlando, Florida
- Grady Memorial Hospital — Atlanta, Georgia
- Arthur M. Blank Hospital — Atlanta, Georgia
- Northwestern Memorial Hospital — Chicago, Illinois
- Comer Children's Hospital — Chicago, Illinois
- University of Chicago Medical Center — Chicago, Illinois
- IU Health Methodist Hospital — Indianapolis, Indiana
- Riley Hospital for Children — Indianapolis, Indiana
- University of Iowa Medical Center — Iowa City, Iowa
- University of Maryland Medical Center — Baltimore, Maryland
- Massachusetts General Hospital — Boston, Massachusetts
- University of Michigan University Hospital — Ann Arbor, Michigan
- Detroit Receiving Hospital — Detroit, Michigan
- Sinai-Grace Hospital — Detroit, Michigan
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.