Who is eligible for clinical trial NCT06940037?

Participants must meet protocol criteria for Aging. Confirm exact inclusion and exclusion requirements with the study coordinator.

Does clinical trial NCT06940037 provide travel or cost reimbursement?

Check with the site coordinator at the participating facility for travel and lodging stipend availability, and for which routine-care costs are covered.

🏛️ Verified NIH Record • Updated 2025-09-15

The Impact of Biological Mechanisms of Aging on Response Variability to Resistance Training in Older Adults (NCT06940037)

🟢 Recruiting Observational / Diagnostic 📋 Clinical Research Protocol Sponsor: Mayo Clinic

🩺 Plain-English Summary (8th-Grade Level)

To critically examine biological, clinical, and behavioral modulators of progressive resistance training-associated exercise response heterogeneity in physical function and whole-body metabolism in older adults.

Who can join: To join this study, participants generally need to meet the listed inclusion criteria (5 items) and avoid the listed exclusions (27 items).

Location: Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University — Boston, Massachusetts

📋 "Do I Qualify?" — 1-Minute Self Screener

Instant Checklist

Check every box below. If you can check all of them, you may meet the study's basic screening requirements (final eligibility is confirmed by the site team).

aged greater than or equal to 65 years
sedentary (Community Healthy Activities Model Program for Seniors physical activity questionnaire to identify and exclude persons engaged in regular (125 min/week or more) moderate intensity physical activity
at risk for mobility disability score of less than or equal to 10 (but greater than 3) on the SPPB
willing to be randomized into HE or PRT
willing to be transported or transport themselves to the clinical sites for the intervention and assessments

Usually NOT eligible if any of the following apply:

Exclusion Criteria:
unwillingness to provide informed consent
participation in lifestyle or pharmacologic intervention trial or structured program of exercise training in the past 6 months
an SPPB score of less than or equal to 3
osteoarthritis or condition with joint pain limiting daily life activities
significant weight loss or gain (7.5% of body weight) in past six months
current anti-coagulant or anti-platelet therapy (Coumadin, Eliquis, Pradaxa, Xarelto, heparin, Lovenox, Plavix)
clinically significant abnormality in any of the screening laboratory values, including those identified as outside of the "normal limits', that are deemed to be of concern for participation in the study by the study physician
acute or terminal illness
Mini Mental State Exam (MMSE) \<23
myocardial infarction in the previous 6 months or other symptomatic coronary artery disease
New York Heart Association Class III or IV congestive heart failure

🔍 Extracted verbatim from the official NIH eligibility criteria. Always confirm with the study coordinator.

📍 All Participating Trial Locations (2 Sites)

Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University — Boston, Massachusetts
Mayo Clinic — Rochester, Minnesota

💰 Cost, Insurance & Patient Rights

100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

🏛️ View Official NIH Record ↗