Who is eligible for clinical trial NCT07084441?

Participants must meet protocol criteria for Adhesive Small Bowel Obstruction. Confirm exact inclusion and exclusion requirements with the study coordinator.

Does clinical trial NCT07084441 provide travel or cost reimbursement?

Check with the site coordinator at the participating facility for travel and lodging stipend availability, and for which routine-care costs are covered.

🏛️ Verified NIH Record • Updated 2026-05-05

Comparison of Outcomes of Management of Bowel Obstruction (NCT07084441)

🟢 Recruiting Phase4 💊 Investigational Drug / Biologic Sponsor: University of Washington

🩺 Plain-English Summary (8th-Grade Level)

The Comparison of Outcomes of Management of Bowel Obstruction (COMBO) trial is a patient-level randomized trial of a short course of dexamethasone + supportive care vs supportive care alone for patients with adhesion-related small bowel obstruction (aSBO). The goal of the COMBO trial is to answer the question: Can Dexamethasone increases the proportion of patients with resolution of aSBO with non-operative management (without complication) based on an established minimal important clinical difference.

Who can join: To join this study, participants generally need to meet the listed inclusion criteria (7 items) and avoid the listed exclusions (8 items).

Location: Columbia University Medical Center — New York, New York

📋 "Do I Qualify?" — 1-Minute Self Screener

Instant Checklist

Check every box below. If you can check all of them, you may meet the study's basic screening requirements (final eligibility is confirmed by the site team).

Adults ≥18 years of age recruited from UWMC
Patients presenting to surgical services through the Emergency Department, diagnosis of SBO, consulted by surgeon, and an urgent or emergency operation is deemed not necessary by surgeon.
Diagnosis of aSBO is established by;
CT findings consistent with diagnosis of SBO; and
signs and symptoms consistent with SBO; and
Adhesions from prior abdominopelvic surgery are the likely cause of SBO (absence of incarcerated hernia, internal hernia, masses, fistula, stricture, volvulus, acute episode of inflammatory bowel disease (IBD) flare, etc.).
Ability to provide written or electronic informed consent in English and answer teach-back questions

Usually NOT eligible if any of the following apply:

Exclusion Criteria:
Signs and symptoms of peritonitis with emergency operation planned
Planned urgent operation within the next 12 hours
Allergy to dexamethasone
Surgery within prior 6 weeks
Unable or unwilling to return or be contacted for and/or complete research surveys
Currently incarcerated in a detention facility or in police custody (patients wearing a monitoring device can be enrolled) at baseline/screening
Individuals with latent infections who have an increased risk of infection.

🔍 Extracted verbatim from the official NIH eligibility criteria. Always confirm with the study coordinator.

📍 All Participating Trial Locations (4 Sites)

Columbia University Medical Center — New York, New York
Harborview Medical Center — Seattle, Washington
UW Medical Center - Northwest — Seattle, Washington
University of Washington Medical Center Montlake — Seattle, Washington

💰 Cost, Insurance & Patient Rights

100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

🏛️ View Official NIH Record ↗