Who is eligible for clinical trial NCT07106450?

Participants must meet protocol criteria for Prediabetes. Confirm exact inclusion and exclusion requirements with the study coordinator.

Does clinical trial NCT07106450 provide travel or cost reimbursement?

Check with the site coordinator at the participating facility for travel and lodging stipend availability, and for which routine-care costs are covered.

🏛️ Verified NIH Record • Updated 2026-08-07

Training Induced Muscle-Adipose EV Communication (NCT07106450)

🟡 Not Yet Recruiting Observational / Diagnostic 🧠 Behavioral & Psychological Program Sponsor: Yuan Wen

🩺 Plain-English Summary (8th-Grade Level)

This study examines how muscle cells communicate with fat cells through tiny packages called extracellular vesicles (EV) during exercise. These vesicles carry important molecules that may affect how the body processes sugar and fat. The research team observed significant variability in the adipose response to exercise, and used this variability to gain further insight into the mechanism through which mature microRNA-1 (miR-1) changes in adipose tissue. The investigators selected six subjects with the highest increase in miR-1 abundance in adipose tissue after exercise and compared them with the six subjects that had the most dramatic decrease in miR-1 abundance after exercise. The research team observed that participants intrinsically vary in their ability to endocytose EV into adipose tissue. It is unclear whether this variance in receptivity is a cause or consequence of the significant difference in EV-delivery of miR-1 to adipose tissue.

Who can join: To join this study, participants generally need to meet the listed inclusion criteria (5 items) and avoid the listed exclusions (8 items).

Location: University of Kentucky — Lexington, Kentucky

📋 "Do I Qualify?" — 1-Minute Self Screener

Instant Checklist

Check every box below. If you can check all of them, you may meet the study's basic screening requirements (final eligibility is confirmed by the site team).

Age 30-55 years
Sedentary lifestyle (exercise \<1 day/week for at least 3 months prior to enrollment)
Able to provide informed consent
For Control Group: BMI \< 27 kg/m², normal glucose tolerance, no more than 1 feature of metabolic syndrome
For Prediabetic Group: BMI \> 30 kg/m², at least 3 features of metabolic syndrome including prediabetes (defined as fasting plasma glucose 100-125 mg/dL OR 2-hour post-load glucose on 75g OGTT 140-199 mg/dL OR HbA1C 5.7-6.4%)

Usually NOT eligible if any of the following apply:

Exclusion Criteria:
Pregnancy (confirmed by pregnancy test in women of childbearing potential)
Type 2 diabetes mellitus
Cardiovascular contraindications to resistance exercise
Medical conditions that would interfere with muscle or adipose tissue biopsy procedures
Use of medications that significantly affect glucose metabolism or exercise response
Active participation in structured exercise programs (\>1 day/week) within 3 months of enrollment
Inability to safely participate in resistance exercise protocol

🔍 Extracted verbatim from the official NIH eligibility criteria. Always confirm with the study coordinator.

📍 All Participating Trial Locations (1 Sites)

University of Kentucky — Lexington, Kentucky

💰 Cost, Insurance & Patient Rights

100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

🏛️ View Official NIH Record ↗