Who is eligible for clinical trial NCT07110376?

Participants must meet protocol criteria for Parkinson Disease. Confirm exact inclusion and exclusion requirements with the study coordinator.

Does clinical trial NCT07110376 provide travel or cost reimbursement?

Check with the site coordinator at the participating facility for travel and lodging stipend availability, and for which routine-care costs are covered.

🏛️ Verified NIH Record • Updated 2026-08-27

Deep Brain Stimulation Neural Recordings of Varied Stimulation During Sleep in Parkinson's Disease (NCT07110376)

🟢 Recruiting Observational / Diagnostic 📋 Clinical Research Protocol Sponsor: The Cleveland Clinic

🩺 Plain-English Summary (8th-Grade Level)

This study employs an exploratory, prospective, single center, naturalistic clinical trial design with a randomized crossover intervention.

Who can join: To join this study, participants generally need to meet the listed inclusion criteria (7 items) and avoid the listed exclusions (5 items).

Location: Cleveland Clinic — Cleveland, Ohio

📋 "Do I Qualify?" — 1-Minute Self Screener

Instant Checklist

Check every box below. If you can check all of them, you may meet the study's basic screening requirements (final eligibility is confirmed by the site team).

Male or female \> 18 years of age
Diagnosed with idiopathic Parkinson Disease
Have bilateral implantation of Medtronic's PerceptTM PC (Medtronic Neurological Division, Minneapolis, MN, USA) Deep Brain Stimulation (DBS) system targeting the subthalamic nucleus (STN) and have had their stimulation settings optimized for a minimum of three months
Report a response score of one or greater on question 1.7 of the Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS) part I;
Demonstrate ability to ambulate independently;
Be capable of providing informed consent;
If taking sleep-supporting medications, dosing must be stable for at least 30 days

Usually NOT eligible if any of the following apply:

Exclusion Criteria:
Presence of neurological diseases other than Parkinson Disease, such as stroke or multiple sclerosis
Active sleep disorders, including narcolepsy, moderate to severe (Apnea-Hypopnea Index\>=15) untreated sleep apnea, uncontrolled restless legs syndrome
Cognitive impairment meeting the criteria for dementia as per the Diagnostic and Statistical Manual of Mental Disorders, 4th Edition (DSM-IV), based on formal neuropsychological evaluation
Ongoing alcohol or substance abuse; Working night shifts or irregular work hours The main concern for vulnerable subjects will be for the possibility of reduced decision-making capacity. For this we intend to exclude individuals who have a diagnosis of dementia.

🔍 Extracted verbatim from the official NIH eligibility criteria. Always confirm with the study coordinator.

📍 All Participating Trial Locations (1 Sites)

Cleveland Clinic — Cleveland, Ohio

💰 Cost, Insurance & Patient Rights

100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

🏛️ View Official NIH Record ↗