Who is eligible for clinical trial NCT07139899?

Participants must meet protocol criteria for Severe Asthma. Confirm exact inclusion and exclusion requirements with the study coordinator.

Does clinical trial NCT07139899 provide travel or cost reimbursement?

Check with the site coordinator at the participating facility for travel and lodging stipend availability, and for which routine-care costs are covered.

🏛️ Verified NIH Record • Updated 2025-11-17

Downstream Effects of Airway Mucus Plugs on 129Xenon MRI in Severe Asthma (NCT07139899)

🟢 Recruiting Interventional Protocol 📊 Observational Clinical Research Sponsor: Bastiaan Driehuys

🩺 Plain-English Summary (8th-Grade Level)

In this study, xenon MRI will be used to evaluate regional functional consequences of mucus plugs in the lungs of patients with severe asthma. Mucus plugs will be identified using CT imaging, and xenon MRI will be used to evaluate ventilation and gas exchange impairments in regions of the lungs corresponding to the airways downstream of mucus plugs.

Who can join: To join this study, participants generally need to meet the listed inclusion criteria (9 items) and avoid the listed exclusions (12 items).

Location: Duke University Medical Center — Durham, North Carolina

📋 "Do I Qualify?" — 1-Minute Self Screener

Instant Checklist

Check every box below. If you can check all of them, you may meet the study's basic screening requirements (final eligibility is confirmed by the site team).

Adequate completion of informed consent process with written documentation
Patients 18 - 65 years old
Physician diagnosis of asthma for \> 1 year
Able to perform reproducible spirometry according to ATS criteria based on clinical PFTs within previous 30 days of enrollment
All racial/ethnic backgrounds may participate
Blood eosinophil count \> 300 cells/μL
Smoking history \<10 pack years
No smoking history (including vapes, cigar, or marijuana use) in the last 3 months
About to initiate asthma therapy with either dupilumab, tezepelumab, or benralizumab as part of their standard of care

Usually NOT eligible if any of the following apply:

Exclusion Criteria:
Respiratory tract infection within the 4 weeks prior to Visit 1
Body mass index (BMI) \> 30 at Visit 1
One-time doses such as intra-articular injections require a 4-week washout prior to Visit 1
Asthma-related ER visit within the previous 4 weeks of Visit 1 or at any time while on the study
Significant concomitant medical illness, including (but not limited to) heart disease, cancer, uncontrolled diabetes, other chronic lung diseases (determined by the Investigator.)
Resting O2 saturation \<90% with maximum supplemental O2 delivered by nasal cannula
Positive urine pregnancy test at Visit 1 or at any time while on the study
Participation in an intervention study (including bronchoscopy) or use of investigative drugs within the past 30 days or plans to enroll in such a trial during the study
Unable or unlikely to complete study assessments in the opinion of the Investigator
Study intervention poses undue risk to patient in the opinion of the Investigator
Conditions that will prohibit MRI scanning determined by the MRI safety screening.

🔍 Extracted verbatim from the official NIH eligibility criteria. Always confirm with the study coordinator.

📍 All Participating Trial Locations (1 Sites)

Duke University Medical Center — Durham, North Carolina

💰 Cost, Insurance & Patient Rights

100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

🏛️ View Official NIH Record ↗