🏛️ Verified NIH Record • Updated 2026-08-12
Personalized Radiotherapy for Individualized Treatment Strategies and Monitoring (PRISM) (NCT07139990)
🟢 Recruiting Phase1 📋 Clinical Research Protocol Sponsor: University of Texas Southwestern Medical Center
🩺 Plain-English Summary (8th-Grade Level)
To characterize feasibility, safety, and/or preliminary efficacy of personalized strategies to adapt standard radiotherapy treatments to individual patient responses.
Who can join: To join this study, participants generally need to meet the listed inclusion criteria (20 items) and avoid the listed exclusions (15 items).
Location: Ut Southwestern Medical Center — Dallas, Texas
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistCheck every box below. If you can check all of them, you may meet the study's basic screening requirements (final eligibility is confirmed by the site team).
Usually NOT eligible if any of the following apply:
- Exclusion Criteria: Cohort A: ⨀ Prior thoracic Radiotherapy Cohort B:
- Prior whole brain Radiotherapy
- Prior surgical resection or focal radiotherapy of a target brain metastasis
- Leptomeningeal disease Cohort C:
- Unresectable or metastatic (nodal or distant) disease
- Synchronous malignancy requiring chemotherapy or other intensive treatment
- Locally recurrent soft tissue sarcoma
- Prior immunotherapy
- Pregnancy or breastfeeding Cohort D:
- Distant metastasis
- Inability to undergo PET-CT for baseline staging
- HPV-positive or p16-positive oropharyngeal cancer
🔍 Extracted verbatim from the official NIH eligibility criteria. Always confirm with the study coordinator.
📍 All Participating Trial Locations (1 Sites)
- Ut Southwestern Medical Center — Dallas, Texas
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.