🏛️ Verified NIH Record • Updated 2026-02-19
PQ203 in Advanced Malignant Tumors Including Triple Negative Breast Cancer (NCT07190469)
🟢 Recruiting Phase1 💊 Investigational Drug / Biologic Sponsor: ProteinQure Inc.
🩺 Plain-English Summary (8th-Grade Level)
The primary purposes of this study are to determine the safety and tolerability of PQ203 in patients with advanced solid tumors including triple negative breast cancer (TNBC), and to determine a recommended Phase 2 dose level for future studies in TNBC.
Who can join: To join this study, participants generally need to meet the listed inclusion criteria (18 items) and avoid the listed exclusions (21 items).
Location: MD Anderson Cancer Center — Houston, Texas
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistCheck every box below. If you can check all of them, you may meet the study's basic screening requirements (final eligibility is confirmed by the site team).
Usually NOT eligible if any of the following apply:
- Exclusion Criteria:
- Patients with primary central nervous system (CNS) malignancies (Patients with stable brain metastases (≥ 4 weeks after a treatment) not requiring steroids or other treatment will be allowed on study).
- Blood transfusion within 14 days of study treatment
- Serious comorbid medical conditions such as heart, lung, kidney, liver, and brain disease that, in the opinion of the enrolling investigator, could interfere with study treatment
- Subjects with history of severe heart disease
- QTc interval using Fridericia's formula (QTcF) \> 470 ms
- Estimated or known weight \> 115 kg (253 lbs)
- Known/suspected pregnancy and/or lactation
- Diastolic blood pressure \< 60 mmHg or \>110 mmHg
- Uncontrolled intercurrent illness
- Long term care facility resident or prisoner
- Any prior receipt of a MMAE-containing drug
🔍 Extracted verbatim from the official NIH eligibility criteria. Always confirm with the study coordinator.
📍 All Participating Trial Locations (4 Sites)
- MD Anderson Cancer Center — Houston, Texas
- NEXT Oncology — San Antonio, Texas
- START Mountain Region — West Valley City, Utah
- Princess Margaret Cancer Centre — Toronto, Ontario
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.