🏛️ Verified NIH Record • Updated 2026-08-24

BEACON-1: Study of AVZO-103 as a Single Agent and in Combination Therapy in Patients With Locally Advanced or Metastatic Urothelial Cancer or Other Solid Tumors (AVZO-103-1001) (NCT07193511)

🟢 Recruiting Phase1 / Phase2 💊 Investigational Drug / Biologic Sponsor: Avenzo Therapeutics, Inc.

🩺 Plain-English Summary (8th-Grade Level)

This study, the first clinical trial of AVZO-103, aims to determine the safety, tolerability, pharmacokinetics, pharmacodynamics, maximum tolerated dose, and antitumor activity of AVZO-103 when administered intravenously as a monotherapy and in combination therapy to patients with locally advanced or metastatic urothelial cancer or other solid tumors.

Who can join: Review the eligibility criteria below.

Location: Avenzo Therapeutics Recruiting Site — San Francisco, California

📋 "Do I Qualify?" — 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria ↗

📍 All Participating Trial Locations (14 Sites)

  • Avenzo Therapeutics Recruiting Site — San Francisco, California
  • Avenzo Therapeutics Recruiting Site — Aurora, Colorado
  • Avenzo Therapeutics Recruiting Site — New Haven, Connecticut
  • Avenzo Therapeutics Recruiting Site — Orlando, Florida
  • Avenzo Therapeutics Recruiting Site — Tampa, Florida
  • Avenzo Therapeutics Recruiting Site — Boston, Massachusetts
  • Avenzo Therapeutics Recruiting Site — New York, New York
  • Avenzo Therapeutics Recruiting Site — Chapel Hill, North Carolina
  • Avenzo Therapeutics Recruiting Site — Cleveland, Ohio
  • Avenzo Therapeutics Recruiting Site — Myrtle Beach, South Carolina
  • Avenzo Therapeutics Recruiting Site — Nashville, Tennessee
  • Avenzo Therapeutics Recruiting Site — Austin, Texas
  • Avenzo Therapeutics Recruiting Site — Houston, Texas
  • Avenzo Therapeutics Recruiting Site — Irving, Texas

💰 Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
🏛️ View Official NIH Record ↗