A Study of Multiparametric Ultrasound Imaging Methods (NCT07270237)

Check every box below. If you can check all of them, you may meet the study's basic screening requirements (final eligibility is confirmed by the site team).

1. Cohort 1 - Feasibility of multiparametric endoscopic ultrasound (mpEUS) imaging of patients at high-risk for pancreatic cancer: Patient Group: those having standard endoscopic ultrasounds because they are at high risk of pancreatic cancer Participants enrolled into the Memorial Sloan Kettering Cancer Center Pancreatic Registry protocol (IRB#: 02-102) will be eligible for this study. Specifically, related individuals without pancreatic cancer who are at-risk for developing pancreatic cancer and meet all of the following criteria (family health history will be self-reported):
2. 10 years younger than the earliest pancreatic cancer diagnosis in the family
3. Be at least 50 years old
4. Be at least 40 years old if diagnosed with FAMMM syndrome (CDKN2A/p16) or Hereditary Pancreatitis (PRSS1, SPINK1/PST1, CTRC, CPA1 or other candidate hereditary pancreatitis genes)
5. Be at least 35 years old if diagnosed with Peutz-Jeghers syndrome (STK11 aka LKB1)
6. Not pregnant and not Nursing
7. Relatives at least 21 years old with other high-risk clinical criteria that warrants pancreatic cancer surveillance or follow-up as determined by the project leader (Dr. Vineet Rolston)
8. Must agree to be contacted for follow-up
9. Must satisfy at least one of the following 4 criteria:
10. Have at least two affected relatives who are a first-degree relative to each other, of whom at least one is a first degree relative to the individual OR have at least two affected first-degree relatives on the same side of the family.
11. Have at least one first- or second-degree affected relative and have germline genetic test results that confirm a likely pathogenic or pathogenic variant in at least one of the following genes:
12. APC (Familial Adenomatous Polyposis (FAP) and Attenuated FAP syndrome

🔍 Extracted verbatim from the official NIH eligibility criteria. Always confirm with the study coordinator.

📍 All Participating Trial Locations (7 Sites)

• Memorial Sloan Kettering Basking Ridge (Consent Only) — Basking Ridge, New Jersey
• Memorial Sloan Kettering Monmouth (Consent Only) — Middletown, New Jersey
• Memorial Sloan Kettering Bergen (Consent Only) — Montvale, New Jersey
• Memorial Sloan Kettering Suffolk - Commack (Limited Protocol Activities) — Commack, New York
• Memorial Sloan Kettering Westchester (Consent Only) — Harrison, New York
• Memorial Sloan Kettering Cancer Center (All Protocol Activities) — New York, New York
• Memorial Sloan Kettering Nassau (Consent Only) — Uniondale, New York

💰 Cost, Insurance & Patient Rights

• 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
• Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
• Voluntary Participation: You may withdraw at any time without affecting your standard medical care.