The GLUCID Study: Effect of Alcohol Reduction and Probiotic Interventions on Cognition and Brain Glucose Metabolism in Normal Aging Adults Who Are High-Risk Alcohol Drinkers (NCT07415707)
🩺 Plain-English Summary (8th-Grade Level)
The goal of this pilot study is to explore a combination of two interventions: (1) a behavioral alcohol-reduction intervention using motivational interviewing, and (2) a blinded probiotic microbiome or placebo intervention. The study examines whether these interventions improve cognitive and neurophysiological function, including brain metabolism, in older adults who are high-risk alcohol drinkers.
Who can join: To join this study, participants generally need to meet the listed inclusion criteria (5 items) and avoid the listed exclusions (18 items).
Location: University of Miami — Miami, Florida
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistCheck every box below. If you can check all of them, you may meet the study's basic screening requirements (final eligibility is confirmed by the site team).
Usually NOT eligible if any of the following apply:
- Exclusion Criteria:
- BMI ≥ 35
- Fasting Glucose \> 125 mg/dL
- Current or previously diagnosed with Type 1 or 2 Diabetes
- Requires the use of insulin and/or other glucose lowering agents
- Unable to fast for 12 hours
- Past serious alcohol withdrawal symptoms
- MRI Contraindications (e.g., certain devices and implants, claustrophobic)
- Diagnosed with a neurodegenerative disease (e.g., Alzheimer's Disease)
- Diagnosed with a psychotic disorder
- Current substance dependence diagnosis (except for mild or moderate alcohol)
- Consumption of over 300 drinks in the past 30 days
🔍 Extracted verbatim from the official NIH eligibility criteria. Always confirm with the study coordinator.
📍 All Participating Trial Locations (1 Sites)
- University of Miami — Miami, Florida
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.