Vascular Intervention Strategies Trial for Alzheimer's (NCT07447206)
๐ฉบ Plain-English Summary (8th-Grade Level)
The proposed pharmacist-led study is a feasibility pilot trial for the management of vascular risk factors of hypertension and hypercholesterolemia in 10 APOE ฮต4 carriers, 50-75, at-risk for dementia. All participants will receive angiotensin receptor blockers (ARBs) for high blood pressure, and hydrophilic statins (or a non-statin alternative) for high cholesterol over a six-month period.
Who can join: To join this study, participants generally need to meet the listed inclusion criteria (7 items) and avoid the listed exclusions (19 items).
Location: Clinical Sciences Building (CSC) โ Los Angeles, California
๐ "Do I Qualify?" โ 1-Minute Self Screener
Instant ChecklistCheck every box below. If you can check all of them, you may meet the study's basic screening requirements (final eligibility is confirmed by the site team).
Usually NOT eligible if any of the following apply:
- Exclusion Criteria:
- One minute standing SBP \< 110 mm Hg
- Arm circumference prevents from accurate BP measurement with use of available devices
- Lost weight of \> 10% unintendedly (within the past 6 months),
- Contraindications to blood pressure and cholesterol lowering medications
- Use of medications prescribed for dementia (e.g., aducanumab, donanemab, lecanemab, donepezil, galantamine, rivastigmine, memantine)
- Evidence of dementia based on medical record review
- Living in a skilled nursing or rehabilitation facility
- Receiving palliative or hospice care
- Bipolar illness or schizophrenia
- Drug or alcohol disorder
- Receiving chronic opioid therapy
๐ Extracted verbatim from the official NIH eligibility criteria. Always confirm with the study coordinator.
๐ All Participating Trial Locations (1 Sites)
- Clinical Sciences Building (CSC) โ Los Angeles, California
๐ฐ Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA ยง 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.