🏛️ Verified NIH Record • Updated 2026-08-04

A Clinical Trial of EYE201/MK-8748 in People With Macular Degeneration (MK-8748-003) (NCT07496567)

🟢 Recruiting Phase2 / Phase3 💊 Investigational Drug / Biologic Sponsor: EyeBiotech Ltd.

🩺 Plain-English Summary (8th-Grade Level)

Researchers are looking for new ways to treat neovascular age-related macular degeneration (NVAMD). Available standard (usual) treatments for NVAMD, such as aflibercept, may not work for every person. Researchers want to learn if a trial medicine called tiespectus (also called MK-8748 or EYE201) can treat NVAMD. The goal of this trial is to learn if tiespectus works as well as aflibercept to treat NVAMD.

Who can join: Review the eligibility criteria below.

Location: Associated Retina Consultants - Gilbert — Gilbert, Arizona

📋 "Do I Qualify?" — 1-Minute Self Screener

Instant Checklist

Full eligibility criteria are available on the official NIH protocol. View the criteria ↗

📍 All Participating Trial Locations (71 Sites)

  • Associated Retina Consultants - Gilbert — Gilbert, Arizona
  • The Retina Partners — Encino, California
  • Northern California Retina Vitreous Associates Medical Group, Inc. — Mountain View, California
  • Orange County Retina Medical Group — Santa Ana, California
  • Retina Consultants of Southern Colorado — Colorado Springs, Colorado
  • RSC Research LLC — Denver, Colorado
  • Retina Consultants of Southern Colorado — Pueblo, Colorado
  • Connecticut Eye Consultants, P.C. — Danbury, Connecticut
  • Retina Consultants, P.C. — Manchester, Connecticut
  • Retina Group of New England — Waterford, Connecticut
  • Retina Group of Florida — Fort Myers, Florida
  • Florida Retina Institute — Orlando, Florida
  • Retina Group of Florida (Site 065) — Sarasota, Florida
  • Center for Retina and Macular Disease (Site 062) — Winter Haven, Florida
  • Illinois Retina Associates — Joliet, Illinois
  • University Retina & Macula Associates, P.C. — Lemont, Illinois
  • Wolfe Eye Clinic — West Des Moines, Iowa
  • Retina Associates, LLC — Lenexa, Kansas
  • Butchertown Clinical Trials — Louisville, Kentucky
  • Maine Eye Center (Site 097) — Portland, Maine
  • Mid Atlantic Retina Specialists — Hagerstown, Maryland
  • Retina Research Institute at New England Retina Consultants, PC — Springfield, Massachusetts
  • Retina Consultants of Minnesota — Edina, Minnesota
  • Envision Ocular, LLC — Bloomfield, New Jersey
  • Long Island Vitreoretinal Consultants / Vitreoretinal Consultants of NY — Great Neck, New York

💰 Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
🏛️ View Official NIH Record ↗