Safety and Efficacy of a Single Dose of Gruticibart to Prevent CRT (NCT07498517)
🩺 Plain-English Summary (8th-Grade Level)
This phase II trial studies how well gruticibart works in reducing the incidence of catheter-related thrombosis (CRT) blood clots in patients with a central venous catheter (CVC) inserted. Many patients develop blood clots from their catheters and can have pain, swelling, and other symptoms. They also often require blood thinners, which can increase the risk of bleeding. Gruticibart, a type of drug called a monoclonal antibody, may prevent blood clots caused by a catheter.
Who can join: To join this study, participants generally need to meet the listed inclusion criteria (11 items) and avoid the listed exclusions (13 items).
Location: OHSU Knight Cancer Institute — Portland, Oregon
📋 "Do I Qualify?" — 1-Minute Self Screener
Instant ChecklistCheck every box below. If you can check all of them, you may meet the study's basic screening requirements (final eligibility is confirmed by the site team).
Usually NOT eligible if any of the following apply:
- Exclusion Criteria:
- Concurrent enrollment in another therapeutic clinical trial
- Active leukemia (lymphoma and myeloma may be included)
- Primary brain tumors or known brain metastases
- Active infection and/or current use of an oral antibiotic
- At time of enrollment:
- Deranged baseline clotting, where INR \> 1.5
- Known bleeding diathesis
- Use of anticoagulation, either therapeutic or prophylactic, for any indication at enrollment
- -At the discretion of the investigator, any other contraindication to anticoagulation therapy
- Previously documented hypersensitivity to either the drug or excipients.
- Psychiatric illness/social situations, or any other condition, that in the opinion of the investigator, would limit compliance with study requirements.
🔍 Extracted verbatim from the official NIH eligibility criteria. Always confirm with the study coordinator.
📍 All Participating Trial Locations (1 Sites)
- OHSU Knight Cancer Institute — Portland, Oregon
💰 Cost, Insurance & Patient Rights
- 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
- Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
- Voluntary Participation: You may withdraw at any time without affecting your standard medical care.