Who is eligible for clinical trial NCT07506616?

Participants must meet protocol criteria for Membrane Potential Mapping. Confirm exact inclusion and exclusion requirements with the study coordinator.

Does clinical trial NCT07506616 provide travel or cost reimbursement?

Check with the site coordinator at the participating facility for travel and lodging stipend availability, and for which routine-care costs are covered.

🏛️ Verified NIH Record • Updated 2026-05-12

Membrane Potential Mapping with18F-TPP (NCT07506616)

🟡 Not Yet Recruiting Phase1 💊 Investigational Drug / Biologic Sponsor: Yale University

🩺 Plain-English Summary (8th-Grade Level)

In this study, investigators propose to use PET imaging to study the pharmacokinetics of 18F-TPP and develop methods for imaging membrane potential (ΔΨT) in humans.

Who can join: To join this study, participants generally need to meet the listed inclusion criteria (4 items) and avoid the listed exclusions (13 items).

Location: Yale University PET Center — New Haven, Connecticut

📋 "Do I Qualify?" — 1-Minute Self Screener

Instant Checklist

Check every box below. If you can check all of them, you may meet the study's basic screening requirements (final eligibility is confirmed by the site team).

Willing and able to give voluntary written informed consent
Stated willingness to comply with all study procedures and availability for the duration of the study
In good general health as evidenced by medical history, physical examination, ECG, serum/urine biochemistry and hematology tests.
If female of childbearing potential, must agree to use an acceptable method of birth control, as determined by the principal investigator, for the duration of the study.

Usually NOT eligible if any of the following apply:

Exclusion Criteria:
Know structural heart disease (e.g. myocardial infarction)
Abnormal and clinically significant ECG (as determined by the Investigator or his/her designee) at screening.
Laboratory tests with clinically significant abnormalities at screening
Pregnancy or Lactation
MRI incompatible implants (i.e., such as pacemaker, artificial joints, non-removable body piercings) and other contraindications for MRI, such as claustrophobia, having implanted or embedded metal objects/fragments or fragments in the head or body that would present a risk during the MRI scanning procedure, or have worked with ferrous metals either as a vocation or hobby (for example, as a sheet metal worker, welder, or machinist).
Participation in other research studies involving ionizing radiation within one year of the PET scans that would cause the subject to exceed the yearly dose limits followed by the Yale University PET Center.
Subject who has current, past, or anticipated exposure to radiation in the workplace within one year of the proposed research scans that in combination with the study tracer would result in a cumulative exposure that exceeds recommended exposure limits.
Has any condition that, in the opinion of the investigator, would prevent compliance with the study protocol.
Arterial Line Exclusion: Blood donation within eight weeks of the start of the study.
Arterial Line Exclusion: History of a bleeding disorder or are currently taking anticoagulants (such as Coumadin, Heparin, Pradaxa, Xarelto).
Arterial Line Exclusion: Prothrombin Time (PT) and Partial Thromboplastin Time (PTT) greater than 5msec above the upper limit of normal.

🔍 Extracted verbatim from the official NIH eligibility criteria. Always confirm with the study coordinator.

📍 All Participating Trial Locations (1 Sites)

Yale University PET Center — New Haven, Connecticut

💰 Cost, Insurance & Patient Rights

100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

🏛️ View Official NIH Record ↗