Who is eligible for clinical trial NCT07538544?

Participants must meet protocol criteria for Myocarditis Acute. Confirm exact inclusion and exclusion requirements with the study coordinator.

Does clinical trial NCT07538544 provide travel or cost reimbursement?

Check with the site coordinator at the participating facility for travel and lodging stipend availability, and for which routine-care costs are covered.

🏛️ Verified NIH Record • Updated 2026-08-17

MCE Molecular Imaging for Myocarditis (NCT07538544)

🟡 Not Yet Recruiting Early Phase1 📋 Clinical Research Protocol Sponsor: University of Virginia

🩺 Plain-English Summary (8th-Grade Level)

Inflammation of the heart (myocarditis) is a serious condition that can cause heart failure, abnormal heart rhythms, cardiac arrest, and death. Rapid diagnosis of this condition is key to reversing it. The purpose of this study is to determine whether myocarditis such as that which occurs with viral illness, autoimmune conditions, or certain therapies (i.e. immune checkpoint inhibitors) can be diagnosed using a new form of ultrasound imaging of the heart (echocardiography) that uses a contrast agent that is targeted to inflammation (Sonazoid).

Who can join: To join this study, participants generally need to meet the listed inclusion criteria (8 items) and avoid the listed exclusions (8 items).

Location: University of Virginia — Charlottesville, Virginia

📋 "Do I Qualify?" — 1-Minute Self Screener

Instant Checklist

Check every box below. If you can check all of them, you may meet the study's basic screening requirements (final eligibility is confirmed by the site team).

Age ≥18 years of age
At least two of the following manifestations of myocarditis:
new or suspected new high-sensitivity troponin \>3 times upper limit of normal
new or suspected new LV dysfunction with LVEF \<50% or any segmental wall motion abnormality in the absence of prior ischemic event
ECG changes consistent with myocarditis defined as either diffuse ST elevation or ST-T abnormalities that are documented to be new,
unexplained severe ventricular arrhythmias,
Cardiac MR evidence for myocarditis
Predisposing condition or therapy associated with heightened risk of acute myocarditis (i.e. SARS-CoV-2, Parvovirus, Immune checkpoint inhibitors)

Usually NOT eligible if any of the following apply:

Exclusion Criteria:
Inability to obtain consent
High pre-test likelihood for ACS based on ECG and history
Pregnancy or planned pregnancy
Lactation
Allergy to ultrasound contrast agents or eggs
Treatment with potent immunosuppressive therapy beyond corticosteroids
Conditions associated with inflammatory myopathy (SLE, giant cell myocarditis, sarcoidosis, etc.)

🔍 Extracted verbatim from the official NIH eligibility criteria. Always confirm with the study coordinator.

📍 All Participating Trial Locations (1 Sites)

University of Virginia — Charlottesville, Virginia

💰 Cost, Insurance & Patient Rights

100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

🏛️ View Official NIH Record ↗