🏛️ Verified NIH Record • Updated 2026-08-03

AMAZE 4: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Obstructive Sleep Apnoea Treated With Positive Airway Pressure Lose Weight and Improve Sleep Apnoea (NCT07571109)

🟢 Recruiting Phase3 💊 Investigational Drug / Biologic Sponsor: Novo Nordisk A/S

🩺 Plain-English Summary (8th-Grade Level)

This study is being done to look at the efficacy and safety of NNC0487-0111 in participants with overweight or obesity, and obstructive sleep apnoea treated with positive airway pressure. There are 2 study treatments in this study taken as injections under the skin once a week. Participants will either get NNC0487-0111, (the treatment being tested) or Placebo (a treatment that has no active medicine in it) and which treatment participants get is decided by chance.

Who can join: Review the eligibility criteria below.

Location: Dignity Health, Mercy Gilbert — Gilbert, Arizona

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Full eligibility criteria are available on the official NIH protocol. View the criteria ↗

📍 All Participating Trial Locations (92 Sites)

  • Dignity Health, Mercy Gilbert — Gilbert, Arizona
  • DM Clinical — Bradenton, Florida
  • Essence MD Research — Naples, Florida
  • Palm Beach Research Center — West Palm Beach, Florida
  • NeuroTrials Research, Inc. — Atlanta, Georgia
  • Physicians Research Associates — Lawrenceville, Georgia
  • Chicago Research Center, Inc — Chicago, Illinois
  • Weil Cornell Medicine — New York, New York
  • Lillestol Research LLC — Fargo, North Dakota
  • CTI Clinical Research Center — Cincinnati, Ohio
  • Clinical Research Associates of Central PA, LLC — DuBois, Pennsylvania
  • Bogan Sleep Consultants, LLC — Columbia, South Carolina
  • Epic Medical Research — DeSoto, Texas
  • Advanced Neurology Epilepsy and Sleep Center ANESC — El Paso, Texas
  • Biorhythms Center for Integrative Sleep Medicine — El Paso, Texas
  • Houston Pulm Med Res Network — Houston, Texas
  • Sleep Therapy Research Center — San Antonio, Texas
  • Tricoastal Sleep Center — Sugar Land, Texas
  • Rainier Clin Res Ctr Inc — Renton, Washington
  • Seattle Clinical Research Center — Seattle, Washington
  • Woolcock Institute — Macquarie Park, New South Wales
  • University of Sunshine Coast - Vitality Village — Birtinya, Queensland
  • Mater Research - RIO Clinical Trials Unit — South Brisbane, Queensland
  • Nightingale Research Adelaide — Adelaide, South Australia
  • University of Western Australia - Centre for Sleep Science — Crawley, Western Australia

💰 Cost, Insurance & Patient Rights

  • 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
  • Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
  • Voluntary Participation: You may withdraw at any time without affecting your standard medical care.
🏛️ View Official NIH Record ↗