Who is eligible for clinical trial NCT07595263?

Participants must meet protocol criteria for Healthy. Confirm exact inclusion and exclusion requirements with the study coordinator.

Does clinical trial NCT07595263 provide travel or cost reimbursement?

Check with the site coordinator at the participating facility for travel and lodging stipend availability, and for which routine-care costs are covered.

🏛️ Verified NIH Record • Updated 2026-08-21

A Study of Ulonivirine (MK-8507) and Methadone in Healthy Volunteers (MK-8507-019) (NCT07595263)

🟡 Not Yet Recruiting Phase1 💊 Investigational Drug / Biologic Sponsor: Merck Sharp & Dohme LLC

🩺 Plain-English Summary (8th-Grade Level)

This study is designed to determine the effect of ulonivirine (MK-8507) on methadone in the body. Participants will take methadone alone and then methadone with ulonivirine to see if ulonivirine changes how the body processes methadone.

Who can join: To join this study, participants generally need to meet the listed inclusion criteria (4 items) and avoid the listed exclusions (5 items).

Location: Pinnacle Research Group ( Site 0002) — Anniston, Alabama

📋 "Do I Qualify?" — 1-Minute Self Screener

Instant Checklist

Check every box below. If you can check all of them, you may meet the study's basic screening requirements (final eligibility is confirmed by the site team).

The main Inclusion Criteria include but are not limited to:
Is in good health
Has a body mass index (BMI) between \>18 and ≤40 kg/m\^2
Is reliably participating in a methadone maintenance program for at least 2 months prior to Day 1 and is on a documented stable dose of methadone for at least 14 days prior to Day 1

Usually NOT eligible if any of the following apply:

Exclusion Criteria The main Exclusion Criteria include but are not limited to:
Has a history of cancer (malignancy)
Has a history of significant multiple and/or severe allergies, or has had an anaphylactic reaction or significant intolerability to prescription or nonprescription drugs or food
Has tested positive human immunodeficiency virus (HIV) or for a sexually transmitted infection at screening
Is under the age of legal consent

🔍 Extracted verbatim from the official NIH eligibility criteria. Always confirm with the study coordinator.

📍 All Participating Trial Locations (1 Sites)

Pinnacle Research Group ( Site 0002) — Anniston, Alabama

💰 Cost, Insurance & Patient Rights

100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

🏛️ View Official NIH Record ↗