A Study of Lower Dose Radiation Therapy for People With Prostate Cancer (NCT07635238)

Check every box below. If you can check all of them, you may meet the study's basic screening requirements (final eligibility is confirmed by the site team).

1. Documentation of Disease o Patients must have pathologically confirmed prostate adenocarcinoma.
2. Definition of Disease
3. Grade Group (GG) 1, 2, or 3.
4. PSA less than 20 ng/mL prior to starting ADT, if used.
5. Clinical stage of TX, T1 or T2 on digital rectal examination. May have up to radiological stage T3a on MRI. MRI must be performed within 12 months of randomization.
6. MRI-visible tumor(s), all having PIRADS v2.1 scores of 3, 4, or 5. Each tumor should be able to be delineated on T2 and diffusion-weighted imaging (DWI) +/- dynamic contrast-enhanced imaging (DCE).
7. Tumor nodule visible on MRI should be considered able to be boosted by treating clinician (ie meet urethral constraints while maintaining mandatory GTV coverage) and \<2.5cm in maximal dimension.
8. The MRI-defined lesion must be confirmed as malignant on biopsies (Grade group 1, 2, or 3).
9. Patients can be concurrently treated with androgen deprivation therapy (ADT) if this would be standard of care. LHRH analogues, LHRH agonists or Bicalutamide are permitted. ADT is not mandatory where this would usually be omitted. Patients needing greater than 6 months of ADT due to disease parameters should be excluded.
10. No high grade disease (GG3) occult to MRI-defined lesion. As a guide, any pathology for which you would consider surveillance (e.g. GG1, low volume GG2) is allowed outside of the MRI-defined area.
11. No contraindications to MRI (e.g. pacemaker, potentially mobile metal implant, claustrophobia).
12. Prostate volume less than or equal to 90mL.

🔍 Extracted verbatim from the official NIH eligibility criteria. Always confirm with the study coordinator.

📍 All Participating Trial Locations (7 Sites)

• Memorial Sloan Kettering at Basking Ridge (Limited Protocol Activities) — Basking Ridge, New Jersey
• Memorial Sloan Kettering at Monmouth (Limited Protocol Activities) — Middletown, New Jersey
• Memorial Sloan Kettering at Bergen (Limited Protocol Activities) — Montvale, New Jersey
• Memorial Sloan Kettering at Suffolk-Commack (Limited Protocol Activities) — Commack, New York
• Memorial Sloan Kettering at Westchester (Limited Protocol Activities) — Harrison, New York
• Memorial Sloan Kettering Cancer Center (All Protocol Activities) — New York, New York
• Memorial Sloan Kettering at Nassau (Limited Protocol Activities) — Uniondale, New York

💰 Cost, Insurance & Patient Rights

• 100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
• Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
• Voluntary Participation: You may withdraw at any time without affecting your standard medical care.