Who is eligible for clinical trial NCT07756112?

Participants must meet protocol criteria for Wound Healing. Confirm exact inclusion and exclusion requirements with the study coordinator.

Does clinical trial NCT07756112 provide travel or cost reimbursement?

Check with the site coordinator at the participating facility for travel and lodging stipend availability, and for which routine-care costs are covered.

🏛️ Verified NIH Record • Updated 2026-08-04

Dynamics of Wound Healing in Patients With Obesity (NCT07756112)

🟡 Not Yet Recruiting Observational / Diagnostic 🩺 Clinical Procedure Protocol Sponsor: University of Iowa

🩺 Plain-English Summary (8th-Grade Level)

Healing after dental surgery can vary from person to person. This study is being done to understand how body weight (obesity vs. normal weight) may affect healing after tissue is removed from the roof of the mouth during a gum graft procedure. The study will also evaluate whether a healing material made from a participant's own blood, called platelet-rich fibrin (PRF), is comparable in quantity and quality to the standard-of-care collagen plug. First, participants will be classified into obese or normal weight groups. Next, participants will be randomized to receive either collagen plug or platelet-rich fibrin clot during their surgical procedure Then, participants will return for 4 visits up to 30 days from the surgery visit.

Who can join: To join this study, participants generally need to meet the listed inclusion criteria (9 items) and avoid the listed exclusions (7 items).

Location: University of Iowa College of Dentistry and Dental Clinics — Iowa City, Iowa

📋 "Do I Qualify?" — 1-Minute Self Screener

Instant Checklist

Check every box below. If you can check all of them, you may meet the study's basic screening requirements (final eligibility is confirmed by the site team).

Be an adult who is having tissue taken from the roof of the mouth as part of a gum graft procedure.
Be able and willing to give informed consent on their own.
Have good oral hygiene (keep their teeth and gums clean).
Have a healthy roof of the mouth with no unusual shape, disease, or injury.
Not have any active illness affecting their overall health.
Not have a medical condition that can slow wound healing, such as uncontrolled type 2 diabetes.
Not currently pregnant.
Not have received a blood transfusion in the last 3 months.
For normal-weight group (BMI less than than 30 kg/m2, waist circumference less than 35 inches for women or greater than 40 inches for men) or for obesity group (BMI greater than 30 kg/m2, waist circumference greater than 35 inches for women and greater than 40 inches for men).

Usually NOT eligible if any of the following apply:

Exclusion Criteria:
Are unable or unwilling to provide your own informed consent.
Take medications that may affect healing or require changes to the planned surgery.
Have a history of alcohol or drug abuse.
Currently smoke or have smoked in the past.
Have had surgery before in the area where the current procedure will be performed.
Have a history of an autoimmune disease or condition.

🔍 Extracted verbatim from the official NIH eligibility criteria. Always confirm with the study coordinator.

📍 All Participating Trial Locations (1 Sites)

University of Iowa College of Dentistry and Dental Clinics — Iowa City, Iowa

💰 Cost, Insurance & Patient Rights

100% Free Items: The investigational treatment and protocol-required procedures are supplied at zero cost by the sponsor.
Routine Patient Care: Under federal law (ACA § 2709) and many state statutes, routine care costs are covered during participation.
Voluntary Participation: You may withdraw at any time without affecting your standard medical care.

🏛️ View Official NIH Record ↗