83 Recruiting Studies at Duke University Medical Center

Active clinical trials at this research center, sourced directly from the NIH registry.

📍 Durham, North Carolina

All research centers

Recruiting Studies at Duke University Medical Center

🔵 Active, Not Recruiting Interventional Protocol 📊 Observational Clinical Research

Evaluation And Risk Assessment For Persistent Postsurgical Pain After Breast Surgery

Breast Cancer

View Study & Checklist ➔

🔵 Active, Not Recruiting Phase2 💊 Investigational Drug / Biologic

DC Migration Study to Evaluate TReg Depletion In GBM Patients With and Without Varlilumab

Glioblastoma

View Study & Checklist ➔

🔵 Active, Not Recruiting Interventional Protocol 📊 Observational Clinical Research

Exploring Relevant Immune-based Biomarkers and Circulating Tumor Cells During Treatment With Immunotherapy in Genitourinary Malignancies (CTC Immune Based Biomarkers)

Carcinoma, Renal Cell

View Study & Checklist ➔

🔵 Active, Not Recruiting Interventional Protocol 📊 Observational Clinical Research

Perioperative Evaluation of Cerebellar Tumors

Cerebellar Tumors

View Study & Checklist ➔

🔵 Active, Not Recruiting Phase1 💊 Investigational Drug / Biologic

Cancer Peptides Plus GM-CSF and Adjuvant in Breast Cancer

Breast Cancer

View Study & Checklist ➔

🔵 Active, Not Recruiting Phase1 💊 Investigational Drug / Biologic

PEP-CMV in Recurrent MEdulloblastoma/Malignant Glioma

Recurrent Medulloblastoma

View Study & Checklist ➔

🔵 Active, Not Recruiting Phase1 💊 Investigational Drug / Biologic

Assessing the Immunogenicity of pING-hHER3FL

Advanced Cancer

View Study & Checklist ➔

🔵 Active, Not Recruiting Phase1 💊 Investigational Drug / Biologic

D2C7-IT With Atezolizumab for Recurrent Gliomas

Malignant Glioma

View Study & Checklist ➔

🔵 Active, Not Recruiting Phase2 💊 Investigational Drug / Biologic

Nivolumab and Temozolomide Versus Temozolomide Alone in Newly Diagnosed Elderly Patients With GBM

Glioblastoma Multiforme

View Study & Checklist ➔

🔵 Active, Not Recruiting Observational / Diagnostic ⚙️ Medical Device Protocol

REsynchronization Comparison In LBBB and Normal or Mildly Reduced VENTricular Function With CRT (REINVENT-CRT)

Left Ventricular Ejection Fraction

View Study & Checklist ➔

🔵 Active, Not Recruiting Phase2 📋 Clinical Research Protocol

Intratreatment FDG-PET During Radiation Therapy for Gynecologic and Gastrointestinal Cancers

Cancer of the Cervix

View Study & Checklist ➔

🔵 Active, Not Recruiting Observational / Diagnostic 📋 Clinical Research Protocol

Radiotherapy Dose De-escalation in HPV-Associated Cancers of the Oropharynx

Oropharynx Cancer

View Study & Checklist ➔

🔵 Active, Not Recruiting Observational / Diagnostic 🧠 Behavioral & Psychological Program

Improving Women's Function After Pelvic Radiation

Sexual Dysfunction

View Study & Checklist ➔

🔵 Active, Not Recruiting Interventional Protocol 📊 Observational Clinical Research

Eye Plaque Brachytherapy for Ocular Melanoma

Ocular Melanoma

View Study & Checklist ➔

🔵 Active, Not Recruiting Phase4 💊 Investigational Drug / Biologic

The PASTDUe Nutrition Ecosystem Project (PASTDUe)

Diet, Healthy

View Study & Checklist ➔

🔵 Active, Not Recruiting Observational / Diagnostic 🧠 Behavioral & Psychological Program

Onco-primary Care Networking to Support TEAM-based Care

Blood Pressure

View Study & Checklist ➔

🔵 Active, Not Recruiting Interventional Protocol 📊 Observational Clinical Research

Duke COVID-19 Shared Data and Specimen Repository

COVID-19

View Study & Checklist ➔

🟡 Not Yet Recruiting Observational / Diagnostic 🧠 Behavioral & Psychological Program

Mitigating Racial Disparities in Shared Decision Making in the Intensive Care Unit

Health Care Disparities

View Study & Checklist ➔

🟡 Not Yet Recruiting Observational / Diagnostic 📋 Clinical Research Protocol

Shared Decision Making to Address Racial Disparities in Oral Anticoagulation in NVAF

Atrial Fibrillation

View Study & Checklist ➔

🟡 Not Yet Recruiting Observational / Diagnostic ⚙️ Medical Device Protocol

ORASIS in Breast Reconstruction

DIEP Flap

View Study & Checklist ➔

🟡 Not Yet Recruiting Observational / Diagnostic ⚙️ Medical Device Protocol

Rehabilitation and Sex Therapy to Optimize Recovery After Prostate Cancer Treatment

Prostate Cancer

View Study & Checklist ➔

🟡 Not Yet Recruiting Observational / Diagnostic 📋 Clinical Research Protocol

Duke Cardiometabolic Prevention Clinic's Impact on High-risk Cardiovascular Patients With Uncontrolled Risk Factors

ASCVD

View Study & Checklist ➔

🟡 Not Yet Recruiting Phase3 💊 Investigational Drug / Biologic

Liposomal Amphotericin B and Flucytosine Antifungal Strategy for Talaromycosis (LAmB-FAST)

Talaromycosis

View Study & Checklist ➔

🟡 Not Yet Recruiting Phase1 💊 Investigational Drug / Biologic

A Widely Inclusive, Hybrid-Decentralized Pilot Trial Utilizing β-hydroxy-β-methylbutyrate to Lower IGFBP7 Levels in People With ALS

Amyotrophic Lateral Sclerosis ALS

View Study & Checklist ➔

🟡 Not Yet Recruiting Observational / Diagnostic 🧠 Behavioral & Psychological Program

Teams Engaged in Accessible Mental Health Interventions for Lupus Erythematosus and Dermatomyositis Stress

Lupus

View Study & Checklist ➔

🟡 Not Yet Recruiting Phase2 💊 Investigational Drug / Biologic

Upfront Chemotherapy With Radiation Therapy (CRT) Followed by Chemotherapy in Localized Esophageal Adenocarcinoma

Esophageal Adenocarcinoma

View Study & Checklist ➔

🟡 Not Yet Recruiting Phase4 💊 Investigational Drug / Biologic

SPARK Study - Sympathetic Periarterial Radial Block in Healthy Volunteers

Healthy Volunteers

View Study & Checklist ➔

🟡 Not Yet Recruiting Observational / Diagnostic 🧠 Behavioral & Psychological Program

Pilot Feasibility Study With Doulas

Post Partum

View Study & Checklist ➔

🟢 Recruiting Observational / Diagnostic 📋 Clinical Research Protocol

A Study of Facilitators and Barriers to Improve Acute Kidney Injury in Children Through Mobile Health Intervention

Acute Kidney Injury

View Study & Checklist ➔

🟢 Recruiting Phase1 💊 Investigational Drug / Biologic

ViCToRy: Vorasidenib in Combination With Tumor Specific Peptide Vaccine for Recurrent IDH1 Mutant Lower Grade Gliomas

Low Grade Glioma of Brain

View Study & Checklist ➔

🟢 Recruiting Interventional Protocol 📊 Observational Clinical Research

Duke Lupus Registry

Systemic Lupus Erythematosus

View Study & Checklist ➔

🟢 Recruiting Interventional Protocol 📊 Observational Clinical Research

GBE Deficiency (GSD IV and APBD) Natural History Study

Glycogen Storage Disease Type IV

View Study & Checklist ➔

🟢 Recruiting Observational / Diagnostic 🧠 Behavioral & Psychological Program

Weight Management After Cancer for Survivors in Rural Communities

Breast Cancer Survivorship

View Study & Checklist ➔

🟢 Recruiting Phase2 💊 Investigational Drug / Biologic

Hyperpolarized 129Xe MRI for Imaging Pulmonary Function

Interstitial Lung Disease

View Study & Checklist ➔

🟢 Recruiting Interventional Protocol 📊 Observational Clinical Research

Opportunistic PK/PD Trial in Critically Ill Children (OPTIC)

Cardiac Disease

View Study & Checklist ➔

🟢 Recruiting Observational / Diagnostic ⚙️ Medical Device Protocol

Cervical Cancer Detection Using Optical Spectroscopy

Cervical Cancer

View Study & Checklist ➔

🟢 Recruiting Phase1 💊 Investigational Drug / Biologic

Phase 1 Trial of D2C7-IT in Combination With 2141-V11 for Recurrent Malignant Glioma

Glioma, Malignant

View Study & Checklist ➔

🟢 Recruiting Phase2 💊 Investigational Drug / Biologic

129 Xenon MRI as a Biomarker for Diagnosis and Response to Therapy in Pulmonary Arterial Hypertension (PAH)

Pulmonary Arterial Hypertension

View Study & Checklist ➔

🟢 Recruiting Interventional Protocol 📊 Observational Clinical Research

Advancing Identification of Circadian Delay in ADHD Youth: Associations With Clinical Heterogeneity and Cognition

ADHD - Attention Deficit Disorder With Hyperactivity

View Study & Checklist ➔

🟢 Recruiting Phase2 💊 Investigational Drug / Biologic

Pulmonary Hypertension SOLAR

Interstitial Lung Disease

View Study & Checklist ➔

🟢 Recruiting Interventional Protocol 📊 Observational Clinical Research

Cognitive and Neurological Pathologies in Pompe Disease

Pompe Disease

View Study & Checklist ➔

🟢 Recruiting Observational / Diagnostic 📋 Clinical Research Protocol

CVFs in SIH: EID vs. PCD CTM

Spontaneous Intracranial Hypotension

View Study & Checklist ➔

🟢 Recruiting Interventional Protocol 📊 Observational Clinical Research

Delayed-Enhancement Cardiovascular Magnetic Resonance in Patients With Sarcoidosis

Sarcoidosis

View Study & Checklist ➔

🟢 Recruiting Phase1 / Phase2 💊 Investigational Drug / Biologic

D2C7-IT and 2141-V11 in Newly Diagnosed GBM Patients

Newly Diagnosed MGMT Unmethylated Glioblastoma

View Study & Checklist ➔

🟢 Recruiting Phase2 💊 Investigational Drug / Biologic

Xenon MRI Pulm Hypertension

Pulmonary Hypertension

View Study & Checklist ➔

🟢 Recruiting Phase1 💊 Investigational Drug / Biologic

A Feasibility Study Utilizing Immune Recall to Increase Response to Checkpoint Therapy

Melanoma

View Study & Checklist ➔

🟢 Recruiting Phase4 💊 Investigational Drug / Biologic

Optimizing Perioperative Analgesia to Lower Pain Following Cleft Palate Surgery

Cleft Palate

View Study & Checklist ➔

🟢 Recruiting Observational / Diagnostic 📋 Clinical Research Protocol

B6 Administration for Levetiracetam-Associated Neurobehavioral Changes and Epilepsy

Brain Tumor Related Epilepsy (BTRE)

View Study & Checklist ➔

🟢 Recruiting Interventional Protocol 📊 Observational Clinical Research

Natural History Study of Patients With Hypophosphatasia (HPP)

Hypophosphatasia

View Study & Checklist ➔

🟢 Recruiting Observational / Diagnostic 🧠 Behavioral & Psychological Program

Vaginal Dilator Therapy After Pelvic Radiation

Pelvic Radiotherapy

View Study & Checklist ➔

🟢 Recruiting Interventional Protocol 📊 Observational Clinical Research

Determination of CRIM Status and Longitudinal Follow-up of Individuals With Pompe Disease

Pompe Disease

View Study & Checklist ➔

🟢 Recruiting Phase1 💊 Investigational Drug / Biologic

D2C7-IT + 2141-V11 Combination Post-resection in rGBM

Recurrent Glioblastoma IDH Wildtype

View Study & Checklist ➔

🟢 Recruiting Phase2 💊 Investigational Drug / Biologic

129Xe MRI Cardiopulmonary

Interstitial Lung Disease

View Study & Checklist ➔

🟢 Recruiting Interventional Protocol 📊 Observational Clinical Research

Genetic Risk Factors Associated With Antiphospholipid Antibody Syndrome

Antiphospholipid Syndrome

View Study & Checklist ➔

🟢 Recruiting Observational / Diagnostic 📋 Clinical Research Protocol

Neuroimaging of Opioid Phase (OPAL)

Chronic Pain

View Study & Checklist ➔

🟢 Recruiting Phase2 💊 Investigational Drug / Biologic

Lerapolturev (PVSRIPO) in GBM

Recurrent Supratentorial Glioblastoma

View Study & Checklist ➔

🟢 Recruiting Observational / Diagnostic 🧠 Behavioral & Psychological Program

Adaptive Coping Skills Training to Improve Psychological Distress Among Cardiorespiratory Failure Survivors

Depression

View Study & Checklist ➔

🟢 Recruiting Phase4 💊 Investigational Drug / Biologic

Tirzepatide in Idiopathic Intracranial Hypertension Trial

Idiopathic Intracranial Hypertension (IIH)

View Study & Checklist ➔

🟢 Recruiting Interventional Protocol 📊 Observational Clinical Research

Duke APOL1 Research Biorepository

End Stage Kidney Disease

View Study & Checklist ➔

🟢 Recruiting Observational / Diagnostic 📋 Clinical Research Protocol

Siemens Biomarker Multi-modality

Fatty Liver

View Study & Checklist ➔

🟢 Recruiting Early Phase1 💊 Investigational Drug / Biologic

Neurobehavioral Mechanisms Linking Childhood Adversity to Increased Risk for Smoking

Adverse Childhood Experiences

View Study & Checklist ➔

🟢 Recruiting Phase1 💊 Investigational Drug / Biologic

BRiTE - Bispecific T Cell Engager for Patients With Glioblastoma

Newly Diagnosed Glioblastoma

View Study & Checklist ➔

🟢 Recruiting Phase4 💊 Investigational Drug / Biologic

Optimization of Pediatric Tonsillectomy to IMprove AnaLgesia

Pain, Postoperative

View Study & Checklist ➔

🟢 Recruiting Interventional Protocol 📊 Observational Clinical Research

A Long-term Follow-up Study of Gaucher Disease

Gaucher Disease

View Study & Checklist ➔

🟢 Recruiting Phase1 💊 Investigational Drug / Biologic

UCB Transplant of Inherited Metabolic Diseases With Administration of Intrathecal UCB Derived Oligodendrocyte-Like Cells

Adrenoleukodystrophy

View Study & Checklist ➔

🟢 Recruiting Phase1 💊 Investigational Drug / Biologic

Macrophage Regulation of Ozone-Induced Lung Inflammation

Respiratory Viral Infection

View Study & Checklist ➔

🟢 Recruiting Observational / Diagnostic 📋 Clinical Research Protocol

The Effect of Non-invasive Brain Stimulation rTMS on Hand Muscles in Chronic Stroke Patients.

Stroke

View Study & Checklist ➔

🟢 Recruiting Phase2 💊 Investigational Drug / Biologic

Phosphate in Acute Pancreatitis

Pancreatitis

View Study & Checklist ➔

🟢 Recruiting Phase2 💊 Investigational Drug / Biologic

Stool Transplants to Treat Refractory Clostridium Difficile Colitis

Clostridium Difficile Colitis

View Study & Checklist ➔

🟢 Recruiting Phase4 💊 Investigational Drug / Biologic

Project DEDUCE: Digital Envirotyping to Develop Understanding of Cigarette Smoking and the Environment

Smoking

View Study & Checklist ➔

🟢 Recruiting Interventional Protocol 📊 Observational Clinical Research

Retinal Imaging in Neurodegenerative Disease

Alzheimer's Disease

View Study & Checklist ➔

🟢 Recruiting Interventional Protocol 📊 Observational Clinical Research

Downstream Effects of Airway Mucus Plugs on 129Xenon MRI in Severe Asthma

Severe Asthma

View Study & Checklist ➔

🟢 Recruiting Phase2 💊 Investigational Drug / Biologic

Immunomodulation to Optimize Vascularized Composite Allograft Integration for Limb Loss Therapy

Immunosuppression

View Study & Checklist ➔

🟢 Recruiting Observational / Diagnostic 📋 Clinical Research Protocol

A Phase 2 Study of Home Care Following Autologous Hematopoietic Stem Cell Transplantation

Well-being of Caregivers (Caregiver Strain Index)

View Study & Checklist ➔

🟢 Recruiting Observational / Diagnostic ⚙️ Medical Device Protocol

Neurostimulation Versus Therapy for Problems With Emotions

Emotion Regulation

View Study & Checklist ➔

🟢 Recruiting Phase1 / Phase2 💊 Investigational Drug / Biologic

Intestinal Microbiome Transplant in ALS

Amyotrophic Lateral Sclerosis ALS

View Study & Checklist ➔

🟢 Recruiting Observational / Diagnostic 🧠 Behavioral & Psychological Program

Pain With Dementia

Pain

View Study & Checklist ➔

🟢 Recruiting Phase3 💊 Investigational Drug / Biologic

Effects of Combination Medical Therapy Followed by BPA on Right Ventricular-PA Coupling and Hemodynamics in CTEPH

CTEPH

View Study & Checklist ➔

🟢 Recruiting Observational / Diagnostic 🩺 Clinical Procedure Protocol

Abdominal Wall Transplant

Transplant;Failure,Kidney

View Study & Checklist ➔

🟢 Recruiting Observational / Diagnostic 📋 Clinical Research Protocol

Predictors of Pain in Sickle Cell Disease

Sickle Cell Disease

View Study & Checklist ➔

🟢 Recruiting Observational / Diagnostic ⚙️ Medical Device Protocol

Virtual Reality Visual Field Testing as an Alternative in Childhood Eye Disease

Visual Field Defect, Peripheral

View Study & Checklist ➔

🟢 Recruiting Observational / Diagnostic ⚙️ Medical Device Protocol

Transcranial Magnetic Brain Stimulation to Reduce Cannabis Use in Heavy Cannabis Users

Cannabis

View Study & Checklist ➔

🟢 Recruiting Phase2 💊 Investigational Drug / Biologic

129 Xenon Imaging in Patients Treated With Sotatercept

Pulmonary Hypertension

View Study & Checklist ➔